{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:58:49Z","timestamp":1779217129239,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":117,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Tuberculosis (TB) presents with fever, night sweats, and cough. The antituberculous therapy (ATT) used to treat TB affects various systems, including the renal system and the hepatobiliary system. ATT\u2010induced acute tubular necrosis (ATN) can have various presentations, such as fever, vomiting, diarrhea, abdominal pain, oliguria, and cola\u2010colored urine. We present a case of a 56\u2010year\u2010old patient using ATT. He presented with the complaint of altered mental status, vomiting, jaundice, and cola\u2010colored urine. Labs revealed elevated liver enzymes, elevated creatinine, anemia, and thrombocytopenia. The autoimmune profile was normal; however, the biopsy revealed ATN. In addition to supportive management, hemodialysis and steroid therapy were initiated. Discontinuation of rifampin along with continuation of modified ATT therapy led to improved renal function tests, platelet counts, and Hb levels.<\/jats:p>","DOI":"10.1155\/crin\/7336365","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:52:18Z","timestamp":1777445538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rifampin: The Cause of Acute Tubular Injury\u2014A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4768-5463","authenticated-orcid":false,"given":"Muhammad Umer","family":"Arif","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0585-0405","authenticated-orcid":false,"given":"Areeba","family":"Farooq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9589-7632","authenticated-orcid":false,"given":"Harjinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0610-8600","authenticated-orcid":false,"given":"Muhammad Talha","family":"Javaid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4244-8682","authenticated-orcid":false,"given":"Mudassar","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2023.07.013"},{"key":"e_1_2_9_2_2","doi-asserted-by":"crossref","unstructured":"De VrieseA. S. RobbrechtD. L. VanholderR. C. VogelaersD. P. andLameireN. H. Rifampicin-Associated Acute Renal Failure: Pathophysiologic Immunologic and Clinical Features American Journal of Kidney Diseases 1998 31 no. 1 108\u2013115.","DOI":"10.1053\/ajkd.1998.v31.pm9428460"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.31482\/mmsl.2022.026"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1081\/JDI-120038521"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2392883"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_33_24"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.5195\/ijms.2024.1713"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000046326"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/phar.2519"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11020450"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.27746"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37860-5"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.5588\/ijtld.23.0078"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/7336365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crin\/7336365","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/7336365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T06:52:22Z","timestamp":1777445542000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crin\/7336365"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh Prabu","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crin\/7336365"],"URL":"https:\/\/doi.org\/10.1155\/crin\/7336365","archive":["Portico"],"relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7336365"}}