{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:51:51Z","timestamp":1781869911018,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Diabetes insipidus (DI) is a heterogeneous disorder characterised by polyuria and polydipsia due to impaired arginine vasopressin (AVP) secretion or action. We describe a 36\u2010year\u2010old pregnant woman who presented at 28\u2009weeks\u2019 gestation with weakness, severe hypokalaemia from renal potassium wasting, hypernatraemia and polyuria with dilute urine. Vasopressinase\u2010mediated DI was suspected; there was no response to AVP, but desmopressin (dDAVP) produced a rapid clinical improvement, confirming the diagnosis. However, postpartum recurrence of symptoms prompted further evaluation, with imaging suggestive of lymphocytic infundibuloneurohypophysitis, necessitating reinitiation of dDAVP. This case highlights the diagnostic complexity of DI in pregnancy and the need to remain vigilant for central causes, even when vasopressinase\u2010mediated DI is initially suspected.<\/jats:p>","DOI":"10.1155\/crin\/7536497","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:04:54Z","timestamp":1781867094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dual Aetiology of Diabetes Insipidus in Pregnancy: Vasopressinase\u2010Mediated and Central Mechanisms"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9211-0122","authenticated-orcid":false,"given":"Philani Ezekiel","family":"Mkhize","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-0605","authenticated-orcid":false,"given":"Pauli","family":"van Heerden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6389-2660","authenticated-orcid":false,"given":"Tholakele","family":"Sabela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4900-0231","authenticated-orcid":false,"given":"Mogamat Razeen","family":"Davids","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9801-1300","authenticated-orcid":false,"given":"Mogamat-Yazied","family":"Chothia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1530\/edm-15-0078"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2011.11.008"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1953.00240220090013"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-018-0234-6"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/8687054"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-019-2619-6"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-2115(01)00607-8"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00156.2011"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/jci113386"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1989.257.4.f706-r"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10071-24030"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2016.02.005"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.617580"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cophys.2019.10.006"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01132.x"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(89)90060-1"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199102213240803"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejm198402163100707"},{"key":"e_1_2_10_19_2","first-page":"726","article-title":"Transient vasopressin-resistant Diabetes Insipidus of Pregnancy","volume":"68","author":"Ford Jr S. 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