{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T09:00:35Z","timestamp":1780218035542,"version":"3.54.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T00:00:00Z","timestamp":1780185600000},"content-version":"vor","delay-in-days":150,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Gitelman syndrome (GS) is a rare inherited renal salt\u2010wasting tubulopathy characterized by hypokalemia, hypomagnesemia, and hypocalciuria. Its nonspecific presentation often overlaps with that of more common pediatric conditions, leading to delayed diagnosis, particularly in resource\u2010limited settings. We report an 11\u2010year\u2010old boy who presented with progressive weight loss, polyuria, polydipsia, and salt craving. His course was complicated by recurrent episodes of severe hypokalemia and hypomagnesemia, and he was initially evaluated for diabetes mellitus, other endocrine disorders, chronic infections such as tuberculosis, and malnutrition without a definitive diagnosis. During the index admission, he developed acute worsening of muscle weakness associated with severe hypokalemia and hypomagnesemia and biochemical findings consistent with renal salt wasting, supporting a diagnosis of GS in the absence of genetic testing. Management with correction of hypovolemia, electrolyte supplementation, liberal salt intake, and nutritional support led to marked clinical improvement and stabilization of biochemical abnormalities on follow\u2010up. This case highlights the importance of maintaining a high index of suspicion for GS in children presenting with polyuria, polydipsia, salt craving, and unexplained electrolyte disturbances, particularly in resource\u2010limited settings.<\/jats:p>","DOI":"10.1155\/crin\/8879176","type":"journal-article","created":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T08:00:13Z","timestamp":1780214413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gitelman Syndrome in a Child Presenting With Polyuria and Polydipsia: Diagnostic Challenges in a Resource\u2010Limited Setting"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4369-1232","authenticated-orcid":false,"given":"Erneus","family":"Ernest","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9836-0779","authenticated-orcid":false,"given":"Devis","family":"Simbila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,31]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.kint.2016.09.046","article-title":"Gitelman syndrome: Consensus and Guidance from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"91","author":"Blanchard A.","year":"2017","journal-title":"Kidney International"},{"key":"e_1_2_13_2_2","doi-asserted-by":"crossref","DOI":"10.1186\/1750-1172-3-22","article-title":"Gitelman syndrome","author":"Knoers N. V. A. M.","year":"2008","journal-title":"Orphanet Journal of Rare Diseases"},{"key":"e_1_2_13_3_2","unstructured":"Bartter and Gitelman Syndromes in Children: Clinical Manifestations Diagnosis and Management UpToDate 2026 https:\/\/www.uptodate.com\/contents\/bartter-and-gitelman-syndromes-in-children-clinical-manifestations-diagnosis-and-management."},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1681\/asn.2016101057"},{"key":"e_1_2_13_5_2","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/ckj\/sfx118","article-title":"Clinical and Diagnostic Features of Bartter and Gitelman Syndromes","volume":"11","author":"Walsh P. 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