{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T21:04:51Z","timestamp":1773781491302,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":58,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Glomerulonephritis is a prominent cause of chronic kidney disease and encompasses a subset of renal diseases characterized by immune\u2010mediated damage to the basement membrane, the mesangium, or the capillary endothelium. Symptoms in early stages are usually nonspecific and can be easily overlooked. Unfortunately, if not detected early, this may lead to end\u2010stage renal disease. We present a case of a 23\u2010year\u2010old male patient with no family of kidney disease who had proteinuria on routine urinalysis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    A 23\u2010year\u2010old male, nonhypertensive and nondiabetic, with no family history of kidney disease coming in for proteinuria. During pre\u2010employment checkup, patient was noted to have 4+ proteinuria on urinalysis. Creatinine was requested by company doctor with result of 1.05\u2009mg\/dL (eGFR: 104\u2009mL\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    ). Repeat urinalysis was done but still with 4+ proteinuria on urinalysis. Hence, advised consult with a nephrologist due to persistence of proteinuria. Upon consult, workups were done, which revealed hyperuricemia, urate crystals on urinalysis, persistence of 4+ proteinuria, and urine protein creatinine ratio of 2.8 (urine protein: 223.28\u2009mg\/dL and urine creatinine: 79.64\u2009mg\/dL). Patient was started on ACE inhibitor, hypouricemic agent, and advised kidney biopsy for further evaluation of proteinuria. The review of systems was pertinent for hearing impairment and blurring of vision. Kidney biopsy was done in which electron microscopy showed segmental podocyte foot process effacement. The glomerular basement membrane shows lamellation and alternate thickening and thinning. No definite electron\u2010dense deposits are seen in glomerular basement membrane and mesangium. Mean glomerular basement membrane thickness is 299\u2009nm (normal mean glomerular basement membrane thickness in adult males is 373\u2009\u00b1\u200942\u2009nm). He was advised consult with an ophthalmologist and otolaryngologist. Regular checkup, monitoring of renal parameters, and appropriate medications were given.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Although a rare cause of glomerulonephritis, Alport syndrome must be considered in patients presenting with subnephrotic range proteinuria and microscopic hematuria. Thorough history and physical examination and characteristic findings on kidney biopsy can help in the prompt diagnosis of the disease. Multidisciplinary care and early intervention can improve the quality of life and delay the progression to end\u2010stage kidney disease among these patients.\n                  <\/jats:p>","DOI":"10.1155\/crin\/9933123","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:12:01Z","timestamp":1741695121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Alport Syndrome Presenting as Incidental Finding of Proteinuria on Pre\u2010Employment Checkup: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-3481","authenticated-orcid":false,"given":"Abigayle Therese R.","family":"Guiritan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee-Boyd D.","family":"Valencia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia L.","family":"Chicano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"e_1_2_9_1_2","volume-title":"StatPearls","author":"Kazi A. M.","year":"2023"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfq665"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.4103\/jwas.jwas_188_22"},{"key":"e_1_2_9_4_2","volume-title":"StatPearls","author":"Watson S.","year":"2023"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-67910-w"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/cge.14116"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.12.018"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.407"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.0000000000000186"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2023.12.014"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2016.1262266"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/9933123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crin\/9933123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/9933123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:41:28Z","timestamp":1773769288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crin\/9933123"}},"subtitle":[],"editor":[{"given":"Ze\u2019ev","family":"Korzets","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crin\/9933123"],"URL":"https:\/\/doi.org\/10.1155\/crin\/9933123","archive":["Portico"],"relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9933123"}}