{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T17:44:50Z","timestamp":1781027090867,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T00:00:00Z","timestamp":1775174400000},"content-version":"vor","delay-in-days":92,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Nephrology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Lithium is an effective mood stabilizer but may cause nephrogenic diabetes insipidus (NDI) by impairing the renal collecting duct response to arginine vasopressin (AVP). We report a 52\u2010year\u2010old woman on long\u2010term lithium therapy who presented with diarrhea, fatigue, polyuria, and confusion. Initial evaluation showed hypernatremia (serum sodium 156\u2013159\u2009mmol\/L), low urine osmolality (101\u2009mOsm\/kg) despite serum osmolality of 286\u2009mOsm\/kg, daily urine output of 6.5\u20137.5\u2009L, and a lithium level of 1.65\u2009mmol\/L. Renal function was preserved. Intravenous 5% dextrose was administered for free\u2010water replacement. Bicarbonate and potassium supplementation were initiated based on blood gas and biochemical findings consistent with metabolic acidosis (pH: 7.33 and serum bicarbonate: 22.1\u2009mmol\/L) and hypokalemia, requiring potassium supplementation. Lithium was discontinued, and a thiazide\u2010containing regimen was initiated. Without desmopressin, serum sodium normalized to 140\u2009mmol\/L within 72\u2009h, urine output decreased to approximately 2\u2009L\/day, and mental status fully recovered. This case demonstrates that timely recognition and management of lithium\u2010induced NDI may allow recovery of urinary concentrating ability.<\/jats:p>","DOI":"10.1155\/crin\/9998067","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:42:51Z","timestamp":1775281371000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Reversible Nephrogenic Diabetes Insipidus Induced by Lithium: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0162-5729","authenticated-orcid":false,"given":"Sevil","family":"Uygun \u0130likhan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4298-8091","authenticated-orcid":false,"given":"G\u00fclin","family":"Dilken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4519-164X","authenticated-orcid":false,"given":"G\u00f6khan","family":"Haz\u0131ro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0423-4192","authenticated-orcid":false,"given":"Sinem","family":"\u00dclke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2560-2318","authenticated-orcid":false,"given":"Selma","family":"Karaahmeto\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.2215\/cjn.01640408"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2009.43"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1101-4"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.89"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04201205"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-2977(00)00104-2"},{"key":"e_1_2_9_7_2","first-page":"1150","article-title":"Renal Side Effects of Lithium: a 20-year follow-up Study","volume":"33","author":"Aiff H.","year":"2019","journal-title":"Journal of Psychopharmacology"},{"key":"e_1_2_9_8_2","first-page":"1086","article-title":"Lithium Nephrotoxicity: an Update on Pathophysiology and Management","volume":"97","author":"Markowitz G. S.","year":"2020","journal-title":"Kidney International"}],"container-title":["Case Reports in Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/9998067","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crin\/9998067","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crin\/9998067","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T05:42:54Z","timestamp":1775281374000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crin\/9998067"}},"subtitle":[],"editor":[{"given":"Poorani","family":"Gurumallesh Prabu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crin\/9998067"],"URL":"https:\/\/doi.org\/10.1155\/crin\/9998067","archive":["Portico"],"relation":{},"ISSN":["2090-6641","2090-665X"],"issn-type":[{"value":"2090-6641","type":"print"},{"value":"2090-665X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9998067"}}