{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:50:56Z","timestamp":1791874256226,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":284,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Danon disease is a rare, X\u2010linked dominant inherited lysosomal storage disorder that involves a mutation in the lysosomal\u2010associated membrane Protein 2 gene. Mutation in this gene results in severe disease clinical manifestations that may include skeletal and cardiac myopathies, retinopathies, and intellectual disabilities. This case report explores postmortem findings observed in a 25\u2010year\u2010old male donor who succumbed to heart failure secondary to Danon disease. With no transplant history, postmortem findings include hypertrophy, extensive fibrosis, and vacuolization in cardiomyocytes compared with expected anatomical findings in an unaffected patient. This case report is aimed at deepening the understanding of the clinical manifestations of Danon disease, raise awareness, and explore diagnostic approaches and differentials to help identify additional treatment options that may improve patient outcomes.<\/jats:p>","DOI":"10.1155\/crip\/1525653","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:24:39Z","timestamp":1791872679000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postmortem Presentation and Review of Danon Disease: A Rare Metabolic Disorder"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1751-9349","authenticated-orcid":false,"given":"Bryanna Rather","family":"Eguh","sequence":"first","affiliation":[{"name":"Department of Basic Sciences Touro College of Osteopathic Medicine Touro University  Middletown New York USA  touro.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5668-2722","authenticated-orcid":false,"given":"Antonio","family":"Farinhas","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Touro College of Osteopathic Medicine Touro University  Middletown New York USA  touro.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1609-4405","authenticated-orcid":false,"given":"Shilpika","family":"Bagh","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Touro College of Osteopathic Medicine Touro University  Middletown New York USA  touro.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1115-4104","authenticated-orcid":false,"given":"Rachael","family":"Connington","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Touro College of Osteopathic Medicine Touro University  Middletown New York USA  touro.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6551-1263","authenticated-orcid":false,"given":"Stephanie","family":"Klinesmith","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences Touro College of Osteopathic Medicine Touro University  Middletown New York USA  touro.edu"},{"name":"Department of Biomedical Sciences College of Osteopathic Medicine Indiana University of Pennsylvania  Indiana Pennsylvania USA  iup.edu"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/circgen.120.003117"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.114.001105"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.10.005"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ehf2.12823"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/35022604"},{"key":"e_1_2_10_6_2","volume-title":"Gray\u2032s Anatomy: The Anatomical Basis of Clinical Practice","author":"Standring S.","year":"2020"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.01.020"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.842282"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14478"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.recesp.2018.04.027"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2022.03.050"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.11.007"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.01.2004"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2412392"},{"key":"e_1_2_10_15_2","volume-title":"Costanzo Physiology","author":"Costanzo L.","year":"2021"},{"key":"e_1_2_10_16_2","volume-title":"Heart Failure and Ejection Fraction","author":"Golla M. 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