{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T14:47:05Z","timestamp":1776091625731,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T00:00:00Z","timestamp":1737244800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Myoepithelioma\u2010like tumor of the vulvar region (MELTVR) is a rare mesenchymal tumor that typically arises in the female vulva.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Case Presentation:<\/jats:bold>\n                    Here, we report a case of a 48\u2010year\u2010old woman who presented with a 2\u2010year history of subcutaneous mass in the vulvar region. As the mass rapidly increased in the last 2 months, personal slight swelling pain appeared. Histologically, the tumor exhibited a distinctive feature of abundant tumor cells and sparse mucus regions. While each region appeared alternately, the sparse mucus region was about 30% of the whole tumor. The tumor had two types of cells, namely, epithelioid and spindle cells. The tumor\u2010rich region demonstrated a cell type of epithelioid, showing hermaphroditic cytoplasm, the center\u2010located nucleus, and abundant chromatin of fasciculate or cord\u2010braid arrangement, whereas the cell of the mucus region was fusiform or epithelioid with partial vacuole\u2010shaped and small visible nucleolus, exhibiting red\u2010stained cytoplasm and loose chromatin. Immunohistochemically, vimentin, smooth muscle actin (SMA), and P16 were diffuse positive in tumor cells, whereas desmin, cytokeratin (CK), P40, P63, CK5, HMB45, MyoD1, myogenin, S100, and SOX10 were all negative. While the proliferation index of Ki\u201067 was about 7%, the expression of SMARCBl\/lNI\u20101 protein was absent. The pathological diagnosis is myoepithelioma\u2010like tumor of the vulva (right labia majora). Finally, the tumor was surgically and completely removed, and no recurrence or metastasis was found after 6 months of follow\u2010up.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Histologically, the morphology of MELTVR is changeable and variation existed for each individual tumor. Moreover, it needs to be differentiated from various other types of tumors, whereas more reports and studies are required to further clarify MELTVR.\n                  <\/jats:p>","DOI":"10.1155\/crip\/2100330","type":"journal-article","created":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T04:26:29Z","timestamp":1737260789000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myoepithelioma\u2010Like Tumor of the Vulva"],"prefix":"10.1155","volume":"2025","author":[{"given":"Jiansheng","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5446-5028","authenticated-orcid":false,"given":"Qingda","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fangshu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiang","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,19]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000397"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000466"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000523"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12765"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-019-0923-0"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pathol.2019.06.004"},{"key":"e_1_2_8_7_2","volume-title":"WHO Classification of Tumours of Soft Tissue and Bone: WHO Classification of Tumours, vol. 5","author":"Fletcher C.","year":"2013"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181882c54"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20819"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2010.03688.x"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31813c6b85"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181d74bdb"}],"container-title":["Case Reports in Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crip\/2100330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crip\/2100330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crip\/2100330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:43:43Z","timestamp":1773769423000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crip\/2100330"}},"subtitle":[],"editor":[{"given":"George","family":"Adonakis","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crip\/2100330"],"URL":"https:\/\/doi.org\/10.1155\/crip\/2100330","archive":["Portico"],"relation":{},"ISSN":["2090-6781","2090-679X"],"issn-type":[{"value":"2090-6781","type":"print"},{"value":"2090-679X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2100330"}}