{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:23:56Z","timestamp":1791559436870,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":230,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Nonsteroidal anti\u2010inflammatory drugs (NSAIDs) can cause mucosal injury throughout the gastrointestinal tract, yet NSAID\u2010related colonic damage remains underrecognized. We report a rare case of an ulcerated colonic mass mimicking carcinoma in a patient with long\u2010term NSAID exposure. The patient, a 63\u2010year\u2010old man with a history of coronary artery disease and coronary artery bypass grafting more than 25 years earlier, was receiving long\u2010term dual antiplatelet therapy consisting of aspirin (81\u2009mg daily) and clopidogrel (75\u2009mg daily), as well as chronic pantoprazole therapy. He presented with a 4\u2010day history of hematochezia without weight loss. Esophagogastroduodenoscopy revealed no bleeding source, but colonoscopy identified an ulcerated, nonobstructive mass in the cecum and proximal ascending colon. A biopsy revealed colonic mucosa with severe ulceration and granulation tissue. The subsequent right hemicolectomy specimen revealed a 5.5\u2010cm, ill\u2010defined ulcerative mass in the cecum and ascending colon. Microscopically, the cecum and ascending colon showed ulcerated mucosa with fibrosis, reactive changes, and foreign body material deposition, without evidence of malignancy. Immunohistochemical stains for cytomegalovirus (CMV) and herpes simplex virus (HSV) were negative. Following surgery, aspirin and clopidogrel were resumed because of the patient\u2032s cardiovascular risk. Approximately 1 year later, his hemoglobin level was 12.0\u2009g\/dL (6.7\u2009g\/dL before surgery), and no gastrointestinal bleeding, diarrhea, or abdominal pain was documented during that encounter. Because aspirin was continued, a clinical response to medication withdrawal could not be assessed. Based on the medication history, right\u2010sided distribution, and histologic findings, the lesion was considered most consistent with suspected aspirin\u2010associated colopathy presenting as a mass\u2010like lesion. However, the concomitant clopidogrel and pantoprazole use and the absence of a formal aspirin dechallenge limited definitive causal attribution.<\/jats:p>","DOI":"10.1155\/crip\/2605428","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:58:19Z","timestamp":1787137099000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Mass\u2010Forming NSAID\u2010Associated Colopathy Mimicking Right\u2010Sided Colon Cancer: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-4476","authenticated-orcid":false,"given":"Hong","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6895-8285","authenticated-orcid":false,"given":"Sonalben 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