{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:04:57Z","timestamp":1789646697584,"version":"4.0.0"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":259,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008890","name":"University of Dundee","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Non\u2010invasive vaginal urothelial carcinomas (UCs) are extremely rare and are almost always associated with a non\u2010invasive bladder UC. The pathogenesis of these rare vaginal lesions is uncertain. They may represent a primary vaginal tumour or they may arise from a urinary tract UC, in which tumour cells \u201cseed\u201d by non\u2010invasive mechanisms. We describe a case of a non\u2010invasive vaginal UC, occurring 6 years following treatment of a non\u2010invasive bladder UC, managed with an anterior pelvic exenteration and followed up over 5 years. Molecular analysis using a genome\u2010wide single nucleotide polymorphism (SNP) microarray to assess copy number variations and regions of copy number neutral loss of heterozygosity (CN\u2010LOH) was performed on both tumours. These results evidence a clonal relationship between these two tumours indicating that the vaginal tumour is the result of non\u2010invasive tumour \u201cseeding\u201d from the original bladder lesion. To our knowledge this is the first case report to demonstrate clonality between metachronous non\u2010invasive bladder and vaginal UCs.<\/jats:p>","DOI":"10.1155\/crip\/4360431","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:48:19Z","timestamp":1789645699000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of a Non\u2010Invasive Vaginal Urothelial Carcinoma Demonstrating a Clonal Relationship With a Metachronous Non\u2010Invasive Bladder Urothelial Carcinoma"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9962-316X","authenticated-orcid":false,"given":"Cassandra","family":"Hill","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-4609-835X","authenticated-orcid":false,"given":"Noman","family":"Ghazanfar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert Gordon","family":"Hislop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ketan","family":"Rathod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam Mustafa","family":"Nandwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318251eade"},{"key":"e_1_2_10_2_2","first-page":"364","article-title":"Extravesical Pagetoid Spread of Urothelial Carcinoma in Situ. 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