{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:54:00Z","timestamp":1781866440108,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":169,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFF1201300"],"award-info":[{"award-number":["2021YFF1201300"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Yolk sac tumor (YST) of the endometrium is very rare, with fewer than 40 cases reported in the English literature. We here describe a case of primary endometrial YST and discuss the clinicopathological features with a literature review. A 66\u2010year\u2010old Chinese woman presented with abnormal vaginal bleeding for 15 days and a uterine mass for 3 days. The preoperative alpha\u2010fetoprotein (AFP) level was 9652.0\u2009ng\/mL, while other serum tumor markers, including carcinoembryonic antigen (CEA), neuron\u2010specific enolase (NSE), and\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010human chorionic gonadotropin (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010HCG), were 40.2\u2009ng\/mL, 29.19\u2009ng\/mL, and 27.7\u2009mIU\/mL, respectively. Pelvic ultrasound imaging revealed a 7.1 \u00d7 6.6 \u00d7 6.0\u2009cm mass in the endometrial cavity. The patient underwent total abdominal hysterectomy, salpingo\u2010oophorectomy, and partial omental resection. The morphologic and immunohistochemical pattern (cytokeratin+++, Sal\u2010Like Protein 4+++, AFP++, Focal Hepatocyte Nuclear Factor 1 beta+, and Focal Glypican\u20103+) was consistent with a primary YST of the endometrium, and the final pathologic stage was IVb based on the International Federation of Gynecology and Obstetrics (FIGO) staging. Postoperative serum AFP level was 5193.0\u2009ng\/mL 5 days after the operation. Primary endometrial YST is extremely rare. It should be differentially diagnosed from other uterine malignancies. Complete surgical staging combined with chemotherapy may have a better survival impact on endometrial YST.\n                  <\/jats:p>","DOI":"10.1155\/crip\/5517722","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:34:57Z","timestamp":1781865297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Yolk Sac Tumor of the Endometrium: A Case Report and Comprehensive Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0975-6926","authenticated-orcid":false,"given":"Hao","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3898-2615","authenticated-orcid":false,"given":"Yan","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0580-4844","authenticated-orcid":false,"given":"Su-sheng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,19]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2021.100748"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000015144"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1515\/med-2020-0010"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/joim.13778"},{"key":"e_1_2_14_5_2","volume-title":"Primary Yolk Sac Tumor of Endometrium: A Case Report and Literature Review","author":"Shi S.-s.","year":"2022"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000722"},{"key":"e_1_2_14_7_2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1111\/j.1365-2559.2011.03889.x","article-title":"Yolk Sac Tumours Revisited. A Review of Their Many Faces and Names","volume":"60","author":"Nogales F. 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