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Clinical management decisions are increasingly guided by molecular alterations rather than the histological subtype alone. Neurotrophic tropomyosin receptor kinase 1 (\n                    <jats:italic>NTRK1<\/jats:italic>\n                    ) is constitutively activated in multiple tumor types. TRK inhibitors, targeting NTRK fusion proteins, have exhibited notable therapeutic efficacy in some\n                    <jats:italic>NTRK<\/jats:italic>\n                    gene fusion tumors. NTRK fusions with diverse partners have been reported in CNS tumors. Nevertheless,\n                    <jats:italic>MEF2D::NTRK1<\/jats:italic>\n                    fusion cases were only reported in high\u2010grade glioneuronal neoplasms and infantile\u2010type hemispheric glioma. We report a 33\u2010year\u2010old patient with LGG morphological features, but presented a diffuse invasive growth pattern involving the corpus callosum, the third ventricle, the entire anterior cranial base and the suprasellar cistern. Histology showed oligodendrocyte\u2010like cells within an abundant mucinous matrix, with scattered astrocytes and no dense collagen, Rosenthal fibers or glomeruloid microvascular. The nucleoli were inconspicuous and mitotic figure was rare. Next\u2010generation sequencing (NGS) showed it harbored a\n                    <jats:italic>MEF2D::NTRK1<\/jats:italic>\n                    fusion and 22q loss with no additional mutations identified. DNA methylation clustered with pilocytic astrocytoma (PA) and diffuse leptomeningeal glioneuronal tumor (DLGNT). However, according to the tumor\u2032s growth pattern, morphological features, and molecular characteristics, it does not match to PA or DLGNS. This report provides a comprehensive description of the clinical, radiographic, histopathological, immunohistochemical, and molecular characteristics of\n                    <jats:italic>MEF2D::NTRK1<\/jats:italic>\n                    fused LGG with the aim of enhancing the clinical and pathological understanding of\n                    <jats:italic>MEF2D::NTRK1<\/jats:italic>\n                    fused LGG. Patient in this case had benefited from\n                    <jats:italic>NTRK<\/jats:italic>\n                    \u2010targeted therapeutic intervention.\n                  <\/jats:p>","DOI":"10.1155\/crip\/6015225","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:07:23Z","timestamp":1791356843000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult Low\u2010Grade Glioma With\n                    <i>MEF2D::NTRK1<\/i>\n                    Fusion: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1918-3209","authenticated-orcid":false,"given":"Xiuyi","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Pathology and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu China  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