{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:47:11Z","timestamp":1792043231546,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":286,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Plasmablastic lymphoma is a rare, aggressive large B cell lymphoma characterized by plasmablastic morphology, terminal B cell (plasma cell) differentiation, frequent loss of conventional B cell markers, and poor clinical outcomes. Although classically associated with immunodeficiency and Epstein\u2013Barr virus (EBV) infection, plasmablastic lymphoma has also been described as an uncommon mechanism of relapse after CD19\u2010directed chimeric antigen receptor T cell (CAR\u2010T) therapy. We report a 69\u2010year\u2010old man with a remote history of chronic lymphocytic leukemia\/small lymphocytic lymphoma and subsequent refractory diffuse large B cell lymphoma (DLBCL) who developed rapidly progressive, CD19\u2010negative plasmablastic lymphoma approximately 1 month after CD19\u2010directed CAR\u2010T therapy. Although DLBCL was of a nongerminal\u2010center phenotype with expression of pan\u2010B markers including CD19 and lack of CD138, the post\u2010CAR\u2010T transformed lymphoma demonstrated acquisition of plasmablastic morphology and CD138 expression, loss of pan\u2010B markers and negative for EBV by in situ hybridization and HHV8 by immunostaining. Fluorescence in situ hybridization (FISH) on the plasmablastic lymphoma showed a\n                    <jats:italic>MYC::IGH<\/jats:italic>\n                    fusion and low\u2010level MYC copy gain that were absent in the antecedent DLBCL. Disease dissemination was later confirmed on left pleural fluid cytology a few days before the patient passed away. This case highlights EBV and HHV8 negative plasmablastic transformation as a rare but important post\u2010CAR\u2010T relapse pattern and underscores the need for repeat biopsy, comprehensive paired immunophenotyping, and molecular studies in patients with atypical progression after cellular therapy.\n                  <\/jats:p>","DOI":"10.1155\/crip\/6303492","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:08:01Z","timestamp":1792040881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transformation to Plasmablastic Lymphoma Following CD19\u2010Directed CAR T Cell Therapy for Refractory Diffuse Large B Cell Lymphoma: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7054-5627","authenticated-orcid":false,"given":"Sinan G.","family":"Khudhur","sequence":"first","affiliation":[{"name":"Department of Pathology Mayo 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