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The patient presented with exertional dyspnea and was hospitalized for congestive heart failure. Following the development of a urinary tract infection, the patient exhibited signs of sepsis\u2010induced cardiomyopathy (SIC), including myocardial injury and rapid hemodynamic deterioration, leading to death. Autopsy findings indicated SIC, characterized by neutrophil\u2010dominant inflammatory cell infiltration and endothelial damage, which might have been exacerbated by the patient\u2032s preexisting conditions of old myocardial infarction and TKI therapy. This case underscores the multifactorial nature of SIC, suggesting that preexisting old myocardial infarction and TKI therapies can significantly impact the disease\u2032s pathogenesis and progression. It highlights the need for comprehensive management strategies in patients with complex medical histories and the importance of further research to elucidate the underlying mechanisms of SIC.<\/jats:p>","DOI":"10.1155\/crip\/7134352","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T05:40:50Z","timestamp":1767073250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intersection of Tyrosine Kinase Inhibition and Sepsis\u2010Induced 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