{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T15:47:07Z","timestamp":1789487227602,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":257,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Pathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Sinonasal carcinomas encompass a molecularly heterogeneous group of malignancies.\n                    <jats:italic>DEK::AFF2<\/jats:italic>\n                    fusion\u2010associated carcinoma is a recently recognized subtype of nonkeratinizing squamous cell carcinoma characterized by deceptively bland morphology yet clinically aggressive behavior. We report the case of a 67\u2010year\u2010old woman who presented with a rapidly enlarging sinonasal mass with extensive local invasion involving both the intracranial compartment and orbit. Histologically, the tumor was composed of cytologically bland cells with monotonous nuclei and exhibited a combination of exophytic and endophytic growth patterns that closely mimicked a sinonasal papilloma. Although the tumor shows predominantly squamous differentiation, focal extracellular mucin was also present. The brain\u2010invasive foci demonstrated tumor cells in sheets and nests floating within pools of mucin, a pattern focally reminiscent of mucinous adenocarcinoma. RNA sequencing identified a\n                    <jats:italic>DEK::AFF2<\/jats:italic>\n                    fusion with breakpoints at\n                    <jats:italic>DEK<\/jats:italic>\n                    exon 7 and\n                    <jats:italic>AFF2<\/jats:italic>\n                    exon 6, confirming the diagnosis. The tumor demonstrated positive PD\u2010L1 expression with a combined positive score (CPS) of 40 and a low tumor mutational burden (TMB) of 0.5 mutations\/Mb. This case highlights the diagnostic challenges posed by\n                    <jats:italic>DEK::AFF2<\/jats:italic>\n                    fusion\u2010associated carcinoma, underscores the importance of molecular profiling for accurate classification, and demonstrates the aggressive clinical behavior of this rare entity.\n                  <\/jats:p>","DOI":"10.1155\/crip\/7248935","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T13:47:52Z","timestamp":1789480072000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<i>DEK::AFF2<\/i>\n                    Fusion\u2010Associated Sinonasal Carcinoma With Intracranial and Orbital Involvement"],"prefix":"10.1155","volume":"2026","author":[{"given":"Katelyn Elizabeth","family":"Golden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Barlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1378-4476","authenticated-orcid":false,"given":"Hong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4576-5966","authenticated-orcid":false,"given":"David 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