{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:37:58Z","timestamp":1792589878513,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:00:00Z","timestamp":1792540800000},"content-version":"vor","delay-in-days":293,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Surgery"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peptic ulcer disease (PUD) is rare in children, with complications like perforation being especially uncommon. Malaria, a major health burden in endemic regions, is associated with severe complications, but giant duodenal perforation as a direct consequence is remarkably rare. This report presents a 5\u2010year\u2010old girl with a giant duodenal perforation secondary to malaria, highlighting the need for prompt diagnosis and intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 5\u2010year\u2010old girl from a malaria\u2010endemic area presented with fever, vomiting, and diarrhea. Diagnosed with severe malaria, she developed acute abdominal pain and signs of peritonitis. Imaging confirmed duodenal perforation, which was surgically repaired. Postoperative recovery was successful, and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      infection was ruled out.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Giant duodenal perforation can occur as a rare complication of severe malaria in children without typical peptic ulcer risk factors. Early recognition and timely surgical and antimalarial treatment are critical to improving outcomes in malaria\u2010endemic settings.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cris\/5569916","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:38:08Z","timestamp":1792586288000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Giant Duodenal Perforation Secondary to Malaria in a 5\u2010Year\u2010Old Girl: Case Report and Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7568-0484","authenticated-orcid":false,"given":"Ashenafi","family":"Shegaw","sequence":"first","affiliation":[{"name":"Department of Surgery Institute of Health Bule Hora University Teaching Hospital Bule Hora University  Bule Hora Ethiopia  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University  Bule Hora Ethiopia  bhu.edu.et"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,21]]},"reference":[{"key":"e_1_2_16_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.epsc.2013.08.015"},{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6304309"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-021-01769-0"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/896509"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e31804069cc"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.3126\/jucms.v1i3.8766"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.paed.2010.04.002"},{"key":"e_1_2_16_8_2","article-title":"Duodenal Perforation in a 12-Month Old Child With Severe Malaria","volume":"12","author":"Goldman N.","year":"2012","journal-title":"Pan African Medical 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