{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:18:13Z","timestamp":1786115893757,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":216,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Pleomorphic giant cell carcinoma (PGCC) of the prostate is an extremely rare and aggressive malignancy with limited treatment options. We present a case report of metastatic PGCC patients treated with\n                    <jats:sup>177<\/jats:sup>\n                    Lu\u2010PSMA\u2010617 radioligand therapy (Pluvicto) after progression on standard therapies. Both patients had PSMA\u2010avid tumors on imaging. Molecular profiling revealed mutations in hallmark tumor suppressors including TP53, RB1, and PTEN. Both patients initially experienced partial radiographic response, in which one patient achieved stable disease for 9 months posttherapy. These findings suggest that PSMA\u2010radioligand therapy may be a reasonable treatment for PGCC patients, but underscore the need for additional therapeutic options.\n                  <\/jats:p>","DOI":"10.1155\/criu\/1304419","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T06:03:04Z","timestamp":1785996184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleomorphic Giant Cell Carcinoma of the Prostate Treated With Lutetium\u2010177 PSMA"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2886-4772","authenticated-orcid":false,"given":"John Y.","family":"Kwon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8202-6268","authenticated-orcid":false,"given":"John C.","family":"Cheville","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7268-5077","authenticated-orcid":false,"given":"Miguel","family":"Muniz-Rincon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed E.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene D.","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4249-0311","authenticated-orcid":false,"given":"Irbaz","family":"Riaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7643-2836","authenticated-orcid":false,"given":"Dan S.","family":"Childs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9781-4072","authenticated-orcid":false,"given":"Geoffrey","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8777-7343","authenticated-orcid":false,"given":"Oliver","family":"Sartor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4209-3394","authenticated-orcid":false,"given":"Lance C.","family":"Pagliaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0319-0239","authenticated-orcid":false,"given":"Jacob J.","family":"Orme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,5]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2021.151719"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.07.002"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000209841.77595.4b"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-0683-PGCCOT"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03481-7"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001112"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940615)73:12<2936::AID-CNCR2820731210>3.0.CO;2-U"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v2.i1.15"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2009.02.016"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyab045"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2017.04.008"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2223-4683.2015.05.02"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23877"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-020-1341-6"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"e_1_2_13_16_2","first-page":"927","article-title":"Monoclonal Antibodies to a New Antigenic Marker in Epithelial Prostatic Cells and Serum of Prostatic Cancer Patients","volume":"7","author":"Horoszewicz J. 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