{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:33:38Z","timestamp":1773009218291,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Castration\u2010resistant prostate cancer (CRPC) is a heterogeneous and aggressive disease with limited treatment options, particularly in poorly differentiated cases that lack androgen receptor expression and progress rapidly even under conventional therapies. Here, we present a rare case of poorly differentiated CRPC that exhibited a remarkable response to carboplatin and paclitaxel therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>\n                      A 53\u2010year\u2010old man with metastatic, castration\u2010sensitive prostate cancer (cT3bN1M1b, PSA 9.39\u2009ng\/mL, Gleason 4 + 5) underwent androgen deprivation therapy using bicalutamide and leuprorelin. Nine months later, he developed CRPC, despite undetectable PSA levels. A supraclavicular lymph node biopsy revealed a poorly differentiated carcinoma. Immunohistochemistry was negative for PSA and NKX3.1 and positive for CK5\/6. These results excluded neuroendocrine carcinoma and supported a diagnosis of undifferentiated carcinoma. Systemic chemotherapy with carboplatin (area under the curve, five) and paclitaxel (200\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) was initiated. Partial remission was achieved at 2 months, and complete remission was confirmed at 18 months. After 73 cycles, chemotherapy was discontinued, and the patient has remained in remission during follow\u2010up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the potential efficacy of carboplatin and paclitaxel in treating poorly differentiated CRPC, suggesting the need for further investigation into platinum\u2010based regimens for aggressive prostate cancer variants.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/criu\/1722086","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:44:31Z","timestamp":1773002671000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Undifferentiated Castration\u2010Resistant Prostate Cancer Successfully Treated With Carboplatin and Paclitaxel"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6969-9189","authenticated-orcid":false,"given":"Masayuki","family":"Sano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Shimbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin","family":"Ohgita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0172-4524","authenticated-orcid":false,"given":"Naoki","family":"Kanomata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiyasu","family":"Endo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2015.05.003"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.6136"},{"key":"e_1_2_9_3_2","first-page":"s358","article-title":"Current State of Castration-Resistant Prostate Cancer","volume":"19","author":"Petrylak D. 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