{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T10:01:45Z","timestamp":1785232905106,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":208,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100016221","name":"Rowan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    Testicular adult granulosa cell tumors (AGCTs) are exceptionally rare neoplasms that are thought to be the male counterpart of ovarian granulosa cell tumors (GCT). Here, we present a 50\u2010year\u2010old African American male who initially presented with right testicular pain and swelling, with ultrasound revealing a 2.0\u2010cm heterogeneous hypoechoic lesion along the upper pole\/interpolar right testicle with internal vascularity. Microscopic examination was consistent with AGCT, demonstrating monomorphic cells with elongated nuclei containing numerous small grooves, resembling ovarian granulosa cells, and scant cytoplasm arranged in trabeculae and sheets. Immunohistochemical stains of the tumor were positive for inhibin, vimentin, and weakly positive for calretinin, S100, and Ki67 (10%). Next Generation Sequencing (NGS) showed low\u2010level amplifications of\n                    <jats:italic>JAK2<\/jats:italic>\n                    ,\n                    <jats:italic>ERBB3<\/jats:italic>\n                    ,\n                    <jats:italic>CDK4<\/jats:italic>\n                    , and\n                    <jats:italic>MDM2<\/jats:italic>\n                    . No gene fusions or mutations were identified. The patient underwent a radical orchiectomy and remains alive and disease\u2010free at 42 months following diagnosis.\n                  <\/jats:p>","DOI":"10.1155\/criu\/4462826","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:36:40Z","timestamp":1785231400000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adult Granulosa Cell Tumor With Low\u2010Level Amplifications of\n                    <i>JAK2<\/i>\n                    ,\n                    <i>ERBB3<\/i>\n                    ,\n                    <i>CDK4<\/i>\n                    , and\n                    <i>MDM2<\/i>\n                    : A Rare Testicular Tumor"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1474-1184","authenticated-orcid":false,"given":"Christopher","family":"Moran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-4776-234X","authenticated-orcid":false,"given":"Catherine","family":"Skibiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadi","family":"Shojaei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-2535","authenticated-orcid":false,"given":"Jeffrey J.","family":"Tomaszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-4637","authenticated-orcid":false,"given":"Tina 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