{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:53:28Z","timestamp":1791010408658,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"vor","delay-in-days":274,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Urology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background\/Objectives<\/jats:title>\n Recent advancements in genetic research have significantly enhanced the understanding of renal cell carcinoma (RCC), now recognized as a heterogeneous group with distinct genetic features. This case report is aimed at illustrating its genetic diversity and implications for diagnosis and treatment.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A middle\u2010aged man presented with an incidental finding of RCC in the right kidney on computer tomography (CT) performed for a persistent cough. Comprehensive radiological and blood tests were conducted, followed by a total right nephrectomy. Histological examination showed a concurrent appearance of two manifestly different tumors in the kidney. Molecular analyses, including SNP array and next\u2010generation sequencing (NGS), were conducted to identify genetic mutations and assess clonality.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The nephrectomy identified two distinct tumors: a clear cell RCC (ISUP\/WHO grade 3, pT1b) and a papillary RCC (ISUP\/WHO grade 2, pT1a). Molecular analysis confirmed\n VHL<\/jats:italic>\n ,\n TP53<\/jats:italic>\n , and\n SETD2<\/jats:italic>\n mutations in the clear cell RCC, whereas no mutations were detected in the papillary RCC. The SNP array revealed significant chromosomal differences, suggesting the tumors were not clonally related. Follow\u2010up imaging detected an adrenal metastasis from the clear cell RCC. The metastasis showed a\n VHL<\/jats:italic>\n and\n SETD2<\/jats:italic>\n mutation, which undoubtedly proved to be derived from the clear cell RCC.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This case underscores the genetic heterogeneity of RCC and the importance of molecular profiling in guiding diagnosis and treatment. The distinct genetic profiles of the two tumors suggest they are not clonally related, highlighting the complexity of RCC and the need for individualized therapeutic approaches.<\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/criu\/5538985","type":"journal-article","created":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:28:49Z","timestamp":1791008929000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Heterogeneity in Renal Cell Carcinoma: A Case of Concurrent Clear Cell and Papillary Renal Carcinomas"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-5211-5971","authenticated-orcid":false,"given":"Annelies","family":"Kerckhofs","sequence":"first","affiliation":[{"name":"Department of Pathology Antwerp University Hospital Edegem Belgium uza.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phanie","family":"Dautricourt","sequence":"additional","affiliation":[{"name":"Department of Urology Antwerp University Hospital Edegem Belgium uza.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0646-0705","authenticated-orcid":false,"given":"L\u00e9on","family":"van Kempen","sequence":"additional","affiliation":[{"name":"Department of Pathology Antwerp University Hospital Edegem Belgium uza.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6183-9251","authenticated-orcid":false,"given":"Stefan","family":"De Wachter","sequence":"additional","affiliation":[{"name":"Department of Urology Antwerp University Hospital Edegem Belgium uza.be"},{"name":"Department of Urology Antwerp Surgical Training Anatomy and Research Centre (ASTARC) Faculty of Medicine and Health Sciences University of Antwerp Wilrijk Belgium uantwerpen.be"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4794-437X","authenticated-orcid":false,"given":"Ali","family":"Ramadhan","sequence":"additional","affiliation":[{"name":"Department of Pathology Antwerp University Hospital Edegem Belgium uza.be"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2018.10.027"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22893"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04527-x"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2009.02350.x"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2015.10.013"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077691"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-7-21"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01362-2"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3233\/KCA-170008"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/genes12030388"},{"key":"e_1_2_13_11_2","volume-title":"WHO Classification of Tumours - Urinary and Male Genital Tumours","author":"Williamson S. 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