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She was found to have a high titer of voltage\u2010gated calcium channel antibodies (VGCCAs) and was started on immunosuppressive and immunomodulating therapy with no further worsening of her neurological status. Subsequent testing revealed that she was also TG6 antibody\u2013positive, and a gluten\u2010free diet was added to her management, following which improvement in cerebellar N\u2010acetyl\u2010aspartate (NAA) concentration (an index of neuronal health\/integrity) was noted on magnetic resonance spectroscopy (MRS), while her clinical picture remained static.<\/jats:p>","DOI":"10.1155\/crnm\/5563623","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T06:31:28Z","timestamp":1777185088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Case of Voltage\u2010Gated Calcium Channel and TG6 Antibody\u2013Positive Cerebellar Ataxia"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4916-3236","authenticated-orcid":false,"given":"Alberto","family":"Cifelli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2872-9676","authenticated-orcid":false,"given":"Zain","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1045-4239","authenticated-orcid":false,"given":"Eva","family":"Cifelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2542-8954","authenticated-orcid":false,"given":"Marios","family":"Hadjivassiliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,25]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.23.7.764"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/120.8.1279"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.42.10.1944"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.9.1138"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81373-2"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0357-x"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000000222"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26079"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.4103\/nsn.nsn_163_23"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-51892-7.00013-9"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10392"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710771105"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.05.003"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.2378"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5262-8"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/5563623","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crnm\/5563623","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/5563623","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:50:37Z","timestamp":1784213437000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crnm\/5563623"}},"subtitle":[],"editor":[{"given":"Dominic B.","family":"Fee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crnm\/5563623"],"URL":"https:\/\/doi.org\/10.1155\/crnm\/5563623","archive":["Portico"],"relation":{},"ISSN":["2090-6668","2090-6676"],"issn-type":[{"value":"2090-6668","type":"print"},{"value":"2090-6676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-11-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"5563623"}}