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Diagnostic workup revealed anti\u2010glutamic acid decarboxylase 65 limbic encephalitis (anti\u2010GAD65 LE), supported by markedly elevated serum anti\u2010GAD65 antibody titers and a compatible clinical presentation. Following initiation of a 6\u2010month course of intravenous immunoglobulin (IVIG), seizure frequency decreased substantially, from 12 to 16 focal seizures per day to approximately one brief focal seizure per month. This was accompanied by improvements in cognition, psychiatric symptoms, and overall clinical function. This case highlights the potential for meaningful therapeutic response to immunotherapy despite prolonged diagnostic delay.<\/jats:p>","DOI":"10.1155\/crnm\/7926284","type":"journal-article","created":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:23:44Z","timestamp":1785479024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effective Treatment of Anti\u2010GAD65 Limbic Encephalitis\u2013Associated Epilepsy Despite Delayed Immunotherapy: A Brief Report"],"prefix":"10.1155","volume":"2026","author":[{"given":"Ghadah","family":"Bughaith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5695-5856","authenticated-orcid":false,"given":"Ghadeer","family":"Mahdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ashkanani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2016.13"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.01.021"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","first-page":"S42","DOI":"10.1212\/01.wnl.0001051236.68099.63","article-title":"Characterization of GAD65-Specific T Cell Responses in Patients With Stiff-Person Syndrome and Type 1 Diabetes","volume":"103","author":"Shang P.","year":"2024","journal-title":"Neurology"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-018-9105-3"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.754938"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol-2011-000084"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.05.017"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325300"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.756668"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1212\/nxi.0000000000000122"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1941875211413135"},{"key":"e_1_2_10_12_2","article-title":"Delayed Immunotherapy Response in Anti-GAD65 Limbic Encephalitis","volume":"13","author":"Markakis I.","year":"2022","journal-title":"Frontiers in Psychiatry"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2020.577189"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-325275"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/7926284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crnm\/7926284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/7926284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T06:23:45Z","timestamp":1785479025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crnm\/7926284"}},"subtitle":[],"editor":[{"given":"Dominic B.","family":"Fee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crnm\/7926284"],"URL":"https:\/\/doi.org\/10.1155\/crnm\/7926284","archive":["Portico"],"relation":{},"ISSN":["2090-6668","2090-6676"],"issn-type":[{"value":"2090-6668","type":"print"},{"value":"2090-6676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7926284"}}