{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:19:32Z","timestamp":1787908772294,"version":"build-2784847793"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":239,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Neurological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Despite high recanalization rates with mechanical thrombectomy (MT), large\u2010vessel occlusion stroke results in death or dependency in over half of patients. Cerebrolysin, a multimodal neuropeptide preparation, may attenuate ischemia\u2013reperfusion injury and support early neurorehabilitation. We report a 88\u2010year\u2010old woman with moderate prestroke disability who presented 2\u2009h after the onset of right hemiparesis and aphasia due to M2 occlusion of the left middle cerebral artery. She received intravenous tenecteplase followed by MT, achieving complete reperfusion after three passes with no direct complications and no immediate clinical improvement. Directly postprocedure, cerebrolysin 30\u2009mL\/day was initiated as adjunctive treatment. Over the next 24\u2009h, neurological deficits gradually resolved with no hemorrhagic transformation or evident infarct on follow\u2010up CT. As the patient did not require early intensive rehabilitation and regained her prestroke functional status, cerebrolysin was discontinued after three doses. This report is not intended to establish the therapeutic efficacy of short\u2010course adjunctive cerebrolysin. It illustrates how clinical signals from randomized and observational studies can be interpreted for the purpose of individual therapeutic decisions.<\/jats:p>","DOI":"10.1155\/crnm\/9962315","type":"journal-article","created":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:31:17Z","timestamp":1787905877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Very Early Short\u2010Course Cerebrolysin After Tenecteplase and Mechanical Thrombectomy: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9235-8009","authenticated-orcid":false,"given":"Hanna","family":"Zi\u0105bska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-6173","authenticated-orcid":false,"given":"Adam","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6728-2020","authenticated-orcid":false,"given":"Micha\u0142","family":"Karli\u0144ski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)00757-8"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/17562864241246938"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-025-01355-z"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.034947"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1177\/23969873221150022"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.71252"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2025.108515"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/med.21960"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3214-0"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007026.pub7"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-017-3037-z"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.049834"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/17474930251375439"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106767"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-023-03159-w"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2025.1510284"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14936"}],"container-title":["Case Reports in Neurological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/9962315","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crnm\/9962315","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crnm\/9962315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:31:24Z","timestamp":1787905884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crnm\/9962315"}},"subtitle":[],"editor":[{"given":"Semonti","family":"Nandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crnm\/9962315"],"URL":"https:\/\/doi.org\/10.1155\/crnm\/9962315","archive":["Portico"],"relation":{},"ISSN":["2090-6668","2090-6676"],"issn-type":[{"value":"2090-6668","type":"print"},{"value":"2090-6676","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9962315"}}