{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:07:08Z","timestamp":1776668828426,"version":"3.51.2"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":108,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260590"],"award-info":[{"award-number":["82260590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Orthopedics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Cases of malignant melanoma first identified in bone are relatively uncommon. Approximately 4.3% of the patients will have metastasis, among which 23% will have metastasis to the bone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>This article presents a case involving malignant melanoma with a metastatic lesion located at the distal femur, which was the initial symptom observed. The patient was a 21\u2010year\u2010old male who was admitted to the hospital due to intermittent pain in his lower left thigh. Imaging studies indicated bone destruction in the distal left femur, and pathological and immunohistochemical confirmed metastatic malignant melanoma. The patient underwent \u201cresection of the tumor segment from the left distal femur followed by artificial knee arthroplasty,\u201d after which he received chemotherapy according to established protocols for advanced malignant melanoma. Currently, the patient\u2032s condition is stable, and no recurrence or metastasis has been observed upon re\u2010examination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>This article details the diagnosis, treatment, and prognosis of a patient with malignant melanoma bone metastasis originating from an unknown primary lesion. Additionally, it reviews and analyzes relevant literature concerning malignant melanoma bone metastasis, emphasizing that clinicians should provide timely local and systemic interventions for patients presenting with malignant melanoma bone metastasis, even when the primary lesion remains unidentified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>For patients with malignant melanoma bone metastasis with unknown primary site, after a clear pathological diagnosis, surgical intervention and postoperative systemic treatment should be carried out in a timely manner to improve the overall survival rate of the patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/cro\/1437495","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T06:18:32Z","timestamp":1776665912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Malignant Melanoma Bone Metastasis With Unknown Primary Site: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"given":"Cao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-7032","authenticated-orcid":false,"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengming","family":"Ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongqi","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dachang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenying","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-5805","authenticated-orcid":false,"given":"Zuozhang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,19]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/dth.14193"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5413.55469"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.55418\/9781933477107-ch11"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.22115"},{"key":"e_1_2_11_5_2","first-page":"572","article-title":"Survival Rates of Patients With Metastatic Malignant Melanoma","volume":"7","author":"Sandru A.","year":"2014","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_11_6_2","first-page":"62","article-title":"Metastatic Melanoma in the Femur\u2014Case Report with Review of Literature: A Pathologist\u2032s Point of View","volume":"9","author":"Costache M.","year":"2014","journal-title":"Maedica (Bucur)"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(72)80136-3"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01435.x"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/591679"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80251-3"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00292-012-1611-y"},{"key":"e_1_2_11_12_2","first-page":"1017","article-title":"Malignant Melanoma Metastatic to the Cavernous Sinus and Skull With an Unknown Primary Origin: Report of a Case","volume":"20","author":"Nogami K.","year":"1992","journal-title":"No Shinkei geka. 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