{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:11:43Z","timestamp":1778911903967,"version":"3.51.4"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":134,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100018552","name":"Science and Technology Plan Project of Taizhou","doi-asserted-by":"publisher","award":["25ywb17"],"award-info":[{"award-number":["25ywb17"]}],"id":[{"id":"10.13039\/501100018552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Orthopedics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>A diffuse\u2010type tenosynovial giant cell tumor (D\u2010TGCT) is a rare, locally invasive tumor that mainly involves large weight\u2010bearing joints, such as the knees, hips, and ankles. Herein, we report a rare case of D\u2010TGCT of the hip joint in a 14\u2010year\u2010old girl. The patient presented with pain and limited movement without a history of trauma. Owing to the continuous progression of hip synovitis, whole exome sequencing was performed, which identified pathogenic variations in the frizzled class receptor 4 (NM_012193.3:c.379C&gt;T(p.Arg127Cys)) and apolipoprotein B (NM_000384.2:c.10579C&gt;T(p.Arg3527Trp)) genes. APOB mutations are associated with hypercholesterolemia. Magnetic resonance imaging of the right hip joint showed thickening of the synovial membrane with irregular edges, low signal intensity on T1\u2010weighted images, and high signal intensity on PDWI+FS images. Small nodules with low signal intensity and clear boundaries were also observed on both types of images. An arthroscopic examination revealed numerous white synovial, chondromate\u2010like tissues under the articular capsule, and D\u2010TGCT was diagnosed based on the histopathological results. One year after the surgery, the patient had good functional recovery and no tumor recurrence.<\/jats:p>","DOI":"10.1155\/cro\/4675478","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:55:41Z","timestamp":1778910941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tenosynovial Giant Cell Tumor (TGCT) in the Hip Joint With an\n                    <i>APOB<\/i>\n                    Mutation"],"prefix":"10.1155","volume":"2026","author":[{"given":"Yujia","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-2130-0348","authenticated-orcid":false,"given":"Shuqiong","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8526-5938","authenticated-orcid":false,"given":"Hongrui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1210-3570","authenticated-orcid":false,"given":"Hanlong","family":"Xin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.07.005"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.04.022"},{"key":"e_1_2_10_3_2","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2022.102491","article-title":"Best Clinical Management of Tenosynovial Giant Cell Tumour (TGCT): A Consensus Paper From the Community of Experts","volume":"112","author":"Stacchiotti S.","year":"2023","journal-title":"Cancer Treatment Reviews"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2016.11.002"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.5435\/JAAOSGlobal-D-22-00011"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2017.03.016"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.820046"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23220"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-006-0170-9"},{"key":"e_1_2_10_10_2","first-page":"146","article-title":"MR Imaging Features of Pigmented Villonodular Synovitis of the Cervical Spine","volume":"25","author":"Parmar H. 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