{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:58:52Z","timestamp":1781161132070,"version":"3.54.1"},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"vor","delay-in-days":160,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Orthopedics"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n Pyothorax\u2010associated lymphoma (PAL) is an Epstein\u2013Barr virus (EBV)\u2013positive diffuse large B\u2010cell lymphoma developing in the setting of long\u2010standing chronic pyothorax. Neurological involvement due to spinal invasion is extremely rare.<\/jats:p>\n <\/jats:sec>\n \n Case Presentation<\/jats:title>\n An 87\u2010year\u2010old woman with a remote history of pulmonary tuberculosis presented with rapidly progressive paraplegia. Imaging demonstrated chronic right pyothorax with a dorsal epidural mass compressing the spinal cord, continuous with a pleural lesion. A biopsy confirmed EBV\u2010positive diffuse large B\u2010cell lymphoma, consistent with PAL. Surgery was considered but declined by the patient and the family. Therefore, the patient was treated with corticosteroids followed by two cycles of R\u2010CHOP chemotherapy; however, no neurological improvement was observed.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case highlights a rare neurological manifestation of PAL. Clinicians should consider lymphoma infiltration in elderly patients with chronic pyothorax who develop new neurological deficits. Early MRI and biopsy are crucial for accurate diagnosis and management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1155\/cro\/7073090","type":"journal-article","created":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:28:36Z","timestamp":1781159316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Spinal Cord Compression due to Pyothorax\u2010Associated Lymphoma: A Rare Presentation of EBV\u2010Positive Diffuse Large B\u2010Cell Lymphoma"],"prefix":"10.1155","volume":"2026","author":[{"given":"Keita","family":"Yanagisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9170-9135","authenticated-orcid":false,"given":"Junya","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3497-4802","authenticated-orcid":false,"given":"Hiroshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6626-5293","authenticated-orcid":false,"given":"Arata","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.09.021"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.46.5"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl349"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.5858\/2008-132-565-EL"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2603"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.5090\/kjtcs.2015.48.1.82"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000018393"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-013-0238-0"}],"container-title":["Case Reports in Orthopedics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cro\/7073090","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/cro\/7073090","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/cro\/7073090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T06:28:37Z","timestamp":1781159317000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/cro\/7073090"}},"subtitle":[],"editor":[{"given":"Shashank","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":8,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/cro\/7073090"],"URL":"https:\/\/doi.org\/10.1155\/cro\/7073090","archive":["Portico"],"relation":{},"ISSN":["2090-6749","2090-6757"],"issn-type":[{"value":"2090-6749","type":"print"},{"value":"2090-6757","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-12-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"7073090"}}