{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:09Z","timestamp":1790776869792,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":272,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neural tube defects (NTDs) are congenital developmental anomalies resulting from incomplete neural tube closure during early embryonic development. They present a wide range of clinical manifestations along the craniospinal axis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>With only 6.2% of Lebanese women of childbearing age taking folic acid tablets during the adequate period, it is primordial to shed light on cases of NTDs in Lebanon. This case series presents four cases of NTDs that deviate from the conventional \u201czipper closure\u201d model of neural tube development, aligning more with the modern multisite closure approach. This case series showcases the consequences of inadequate intake of folic acid prior to conception in addition to delayed prenatal diagnosis. The four cases are presented in accordance with CARE reporting guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study presents four case reports of NTDs, including iniencephaly, anencephaly, encephalocele, and spina bifida. Each case details the clinical presentation, diagnostic findings, and outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The cases demonstrate various manifestations of NTDs: (1) a case of iniencephaly with hydrocephalus and spina bifida in a 32\u2010week fetus, (2) a case of anencephaly in a 34\u2010week fetus, (3) a case of encephalocele in one fetus of diamniotic dichorionic twins at 37 weeks, and (4) a case of closed spina bifida diagnosed at 36 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>The article explores the embryology, classification, and epidemiology of NTDs. It discusses factors that can contribute to NTDs. We also note the limited prenatal follow\u2010up and care in vulnerable populations in Lebanon. Genetic and environmental factors are also discussed, with a particular focus on the role of folic acid and its metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case series highlights the diverse presentations of NTDs. It further showcases the importance of early diagnosis and management. It also emphasizes the need for folic acid supplementation and the consideration of multiple etiologies in the prevention and understanding of NTDs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crog\/2044243","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:35:22Z","timestamp":1790775322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neural Tube Defects in Resource\u2010Limited Settings: A Lebanese Case Series Highlighting Prevention Gaps and Challenges in Prenatal Diagnosis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Georges","family":"Yared","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Department Lebanese American University  Beirut Lebanon  lau.edu.lb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"El Hajjar","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Department Lebanese American University  Beirut Lebanon  lau.edu.lb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3389-2101","authenticated-orcid":false,"given":"Nidal","family":"Hammoud","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medical Sciences Lebanese University  Beirut Lebanon  ul.edu.lb"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Massaad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Saint George University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-631X","authenticated-orcid":false,"given":"Kariman","family":"Ghazal","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medical Sciences Lebanese University  Beirut Lebanon  ul.edu.lb"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/153537020122600402"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1017\/S096719941800045X"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151586"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-023-05910-7"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2025.11.008"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-025-12444-y"},{"key":"e_1_2_14_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/children12081076"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2017.04.026"},{"key":"e_1_2_14_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412006"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv126"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15800"},{"key":"e_1_2_14_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1741-4520.2006.00104.x"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1996.tb09735.x"},{"key":"e_1_2_14_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10094352"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23177"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-010-0736-y"},{"key":"e_1_2_14_17_2","article-title":"Primary Prevention of Neural Tube Defects","volume":"47","author":"Hage C. 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