{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:49:00Z","timestamp":1775666940252,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":97,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Encephalitis caused by herpes simplex virus 1 (HSV\u20101) has been described in pregnancy, but it\u2019s rare, with less than 20 cases being described in peer\u2010reviewed literature. Physiologic changes in immune response during pregnancy influence the course of HSV\u20101 encephalitis (HSVE) and predispose pregnant women to severe complications. We present a case of herpetic encephalitis in a 12\u2010weeks pregnant patient. In our patient neurologic condition deteriorated despite early diagnosis, appropriate antiviral and antiepileptic treatment, and suppurative neurocritical care, respectively. Disease progression stopped and the patient\u2019s condition improved after pregnancy termination. Improvement could be a consequence of multiple factors, including delayed therapeutic effect of antiviral treatment, the impact of intensive care management, seizure control, and the possibility of spontaneous recovery as part of the natural disease course, respectively. This case highlights the potential severity of HSV\u20101 in early pregnancy and underscores the importance of multidisciplinary management and individualized decision\u2010making in complex clinical situations.<\/jats:p>","DOI":"10.1155\/crog\/8743269","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:56:43Z","timestamp":1775663803000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Herpes Simplex Virus 1 Encephalitis in First Trimester of Pregnancy: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"given":"Matej","family":"Furlan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2708-9175","authenticated-orcid":false,"given":"Miha","family":"Lu\u010dovnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7415-123X","authenticated-orcid":false,"given":"Nina Grasselli","family":"Kmet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,8]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.055"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2024.03.017"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-015-1071-6"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-025-02940-7"},{"key":"e_1_2_9_5_2","first-page":"241","article-title":"Herpes Simplex Encephalitis in Pregnancy","volume":"95","author":"Jurga J.","year":"2024","journal-title":"Ginekologia Polska"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/258391"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.medmal.2017.01.005"},{"key":"e_1_2_9_8_2","unstructured":"World Medical Association World Medical Association Statement on Medically-Indicated Termination of Pregnancy 2022 WMA https:\/\/www.wma.net\/policies-post\/wma-declaration-on-therapeutic-abortion\/."},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.14328"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004092"},{"key":"e_1_2_9_11_2","first-page":"679","article-title":"Acyclovir and Pregnancy: Current Aspects","volume":"18","author":"Haddad J.","year":"1989","journal-title":"Journal de Gyn\u00e9cologie Obst\u00e9trique et Biologie de la Reproduction"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.japh.2024.02.013"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000004459"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-020-00959-7"}],"container-title":["Case Reports in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crog\/8743269","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crog\/8743269","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crog\/8743269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T15:56:45Z","timestamp":1775663805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crog\/8743269"}},"subtitle":[],"editor":[{"given":"Karuna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crog\/8743269"],"URL":"https:\/\/doi.org\/10.1155\/crog\/8743269","archive":["Portico"],"relation":{},"ISSN":["2090-6684","2090-6692"],"issn-type":[{"value":"2090-6684","type":"print"},{"value":"2090-6692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-06-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"8743269"}}