{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T18:13:49Z","timestamp":1793124829835,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Obstetrics and Gynecology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary vulvar cancer is uncommon, accounting for only 3%\u20135% of all gynecological malignancies. Metastases to the vulva are even rarer, and those originating from breast cancer are exceptional, with fewer than 20 cases reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the first case observed at our institution. A 38\u2010year\u2010old woman had been treated for breast cancer. Ten years after completing treatment, she presented with an analgesic\u2010resistant headache, cervical swelling, and vulvar discomfort. Updated staging revealed hepatic, pulmonary, pleural, and bone metastases. Biopsy of the vulvar lesion confirmed metastasis of an infiltrating ductal breast carcinoma. The patient underwent chemotherapy, with disease progression despite treatment. She is currently receiving palliative chemotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early detection of unusual metastatic sites and appropriate management require careful monitoring of women with breast cancer. Pelvic and gynecological examinations should be included in the follow\u2010up of breast cancer patients to detect vulvar or vaginal metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crog\/9936814","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T15:15:56Z","timestamp":1766762156000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Breast Metastasis From Vulvar Carcinoma: Case Report and Review of Literature"],"prefix":"10.1155","volume":"2025","author":[{"given":"Nayssem","family":"Khessairi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2518-3555","authenticated-orcid":false,"given":"Saida","family":"Sakhri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha","family":"Chrigui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ons","family":"Krimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanen","family":"Bouaziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek Ben","family":"Dhiab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"e_1_2_14_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000516"},{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200306000-00011"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-32-9620-6_9"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000920"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930480106"},{"key":"e_1_2_14_6_2","first-page":"637","article-title":"Metastatic Patterns of Invasive Lobular Versus Invasive Ductal Carcinoma of the Breast","volume":"114","author":"Borst M. J.","year":"1993","journal-title":"Surgery"},{"key":"e_1_2_14_7_2","first-page":"910","article-title":"Breast Carcinoma With Vulvar Metastasis","volume":"23","author":"Covington E. E.","year":"1964","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_14_8_2","first-page":"96","article-title":"Bartholin\u2019s Gland Metastases From Breast Cancer: A Case Report","volume":"17","author":"Patsner B.","year":"1996","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_14_9_2","first-page":"61","article-title":"Vulvar Metastasis of Breast Carcinoma. A Case Report","volume":"42","author":"Curtin W. M.","year":"1997","journal-title":"Journal of Reproductive Medicine"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.4977"},{"key":"e_1_2_14_11_2","first-page":"386","article-title":"Vulvar Metastasis From Breast Carcinoma: A Case Report and Review of the Literature","volume":"19","author":"Sindico R.","year":"1998","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_14_12_2","first-page":"147","article-title":"Ductal Breast Carcinoma Metastatic to the Vulva: A Case Report","volume":"22","author":"Porzio G.","year":"2001","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_14_13_2","first-page":"350","article-title":"Breast-Like Cancer of the Vulva: Primary or Metastatic? A Case Report and Review of the Literature","volume":"23","author":"Miliaras D.","year":"2002","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_14_14_2","first-page":"577","article-title":"Breast Cancer Metastatic to the Vulva After Local Recurrence Occurring on a Rectus Abdominis Myocutaneous Flap: A Case Report and Review of the Literature","volume":"24","author":"Valenzano Menada M.","year":"2003","journal-title":"European Journal of Gynaecological Oncology"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.06.034"},{"key":"e_1_2_14_16_2","first-page":"629","article-title":"Breast-Like Vulvar Lesion With Concurrent Breast Cancer: A Case Report and Critical Literature Review","volume":"23","author":"Perrone G.","year":"2009","journal-title":"In Vivo"},{"key":"e_1_2_14_17_2","first-page":"57","article-title":"Metastatic Lobular Carcinoma of the Breast to the Vulva: A Case Report and Review of the Literature","volume":"22","author":"Papaioannou N.","year":"2010","journal-title":"Journal of the Egyptian National Cancer Institute"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e3182293a2f"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2015.05.002"},{"key":"e_1_2_14_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2015.05.005"},{"key":"e_1_2_14_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.14067"},{"key":"e_1_2_14_22_2","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S503901"}],"container-title":["Case Reports in Obstetrics and Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crog\/9936814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crog\/9936814","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crog\/9936814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:03:29Z","timestamp":1773774209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crog\/9936814"}},"subtitle":[],"editor":[{"given":"Karuna","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crog\/9936814"],"URL":"https:\/\/doi.org\/10.1155\/crog\/9936814","archive":["Portico"],"relation":{},"ISSN":["2090-6684","2090-6692"],"issn-type":[{"value":"2090-6684","type":"print"},{"value":"2090-6692","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"9936814"}}