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Isolated splenic metastasis in patients with lung cancer is exceedingly rare, with only 50 cases reported in the literature. We report a case of an asymptomatic, metachronous, isolated splenic metastasis in a 66\u2010year\u2010old female patient diagnosed 18 months after resection of lung adenocarcinoma. The patient underwent diagnostic and therapeutic splenectomy and remained tumor\u2010free for 14 years. To our knowledge, this represents the longest reported survival following an isolated splenic metastasis from lung cancer. This case suggests that in well\u2010selected patients with isolated splenic involvement, aggressive local therapy such as splenectomy can be curative and may lead to exceptional long\u2010term survival.<\/jats:p>","DOI":"10.1155\/crom\/1635762","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T11:28:58Z","timestamp":1776425338000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isolated Metachronous Splenic Metastasis of Lung Adenocarcinoma: Long\u2010Term Survival After Splenectomy"],"prefix":"10.1155","volume":"2026","author":[{"given":"Nina","family":"Wittlin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-1203","authenticated-orcid":false,"given":"Martin","family":"Buess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"Cancer. 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