{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T22:15:18Z","timestamp":1773008118882,"version":"3.50.1"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":64,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Primary mediastinal seminoma is a rare germ cell tumor that predominantly affects young men. Clinical presentation is variable, and diagnosis relies on imaging studies, tumor markers, and histopathological confirmation. This case report describes the diagnostic and therapeutic approach in a patient with mediastinal seminoma, in accordance with CARE guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Report<\/jats:title>\n                    <jats:p>A 33\u2010year\u2010old man presented with hoarseness, progressive dyspnea, dysphagia, and cough. Diagnostic investigation revealed a large mass in the anterior and middle mediastinum, which was confirmed as seminoma by biopsy and immunohistochemical analysis. Treatment with cisplatin\u2010based chemotherapy (BEP regimen) resulted in a favorable response and significant tumor reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early diagnosis and appropriate treatment of primary mediastinal seminoma are essential for achieving a favorable prognosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crom\/3286934","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:14:20Z","timestamp":1773000860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Mediastinal Seminoma: A Diagnostic and Therapeutic Challenge With an Optimistic Outcome"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5337-1267","authenticated-orcid":false,"given":"Stephanie","family":"dos Santos Bueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1131-1182","authenticated-orcid":false,"given":"Roberta","family":"Borin Previtale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9822-1154","authenticated-orcid":false,"given":"Mike","family":"Rocha Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-0061","authenticated-orcid":false,"given":"Klinger","family":"Soares Faico-Filho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,6]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020487"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.07.062"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/med.2017.12.01"},{"key":"e_1_2_10_4_2","volume-title":"Mediastinal Seminoma","author":"Bishop M. A.","year":"2025"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970815)80:4<691::AID-CNCR7>3.0.CO;2-Q"},{"key":"e_1_2_10_6_2","first-page":"1529","article-title":"Testicular Cancer, Version 2.2023, NCCN Clinical Practice Guidelines in Oncology","volume":"21","author":"Gilligan T.","year":"2023","journal-title":"Journal of the National Comprehensive Cancer Network"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13014-022-02013-6"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-7-223"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2195"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/3286934","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crom\/3286934","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/3286934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T20:14:21Z","timestamp":1773000861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crom\/3286934"}},"subtitle":[],"editor":[{"given":"Harleen","family":"Khatra","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crom\/3286934"],"URL":"https:\/\/doi.org\/10.1155\/crom\/3286934","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3286934"}}