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In the following case report, the clinical course and treatment stratification are detailed for a 59\u2010year\u2010old female who originally presented with cervical radiculopathy and was found to have aggressive\u2010type EHE refractory to multiple lines of therapy. In doing so, a novel deletion of the long arm of Chromosome 16 at Position 24, in all cells analyzed, ISCN Karyotype: 46,XX,del(16)(q24)[10] is also identified and may contribute to a more aggressive disease presentation. Ultimately, further scientific contribution is provided by this report to the otherwise limited understanding of this unique malignancy.<\/jats:p>","DOI":"10.1155\/crom\/3387413","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:47:24Z","timestamp":1772988444000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelioid Hemangioendothelioma With a Novel Chromosomal Deletion and an Aggressive Clinical Course: A Case Report and Literature Review"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-4870","authenticated-orcid":false,"given":"Danielle C.","family":"Thor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nowair","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ada Baisre","family":"de Leon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2014.259"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0246958"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23517"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0b013e31815bf8e6"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22073"},{"key":"e_1_2_12_7_2","volume-title":"Classification of Tumours Editorial Board. 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