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We present a case of a 67\u2010year\u2010old female with renal cell cancer treated with ipilimumab and nivolumab who developed aseptic meningitis and hypophysitis. This case highlights the challenges in managing immune\u2010related adverse events and underscores the need for vigilance in monitoring patients receiving ICIs.<\/jats:p>","DOI":"10.1155\/crom\/3517328","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T16:35:26Z","timestamp":1741451726000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Immune Checkpoint Inhibitor\u2013Mediated Aseptic Meningitis and Hypophysitis"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7933-5774","authenticated-orcid":false,"given":"Pavel","family":"Bleik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-8291","authenticated-orcid":false,"given":"Panisara","family":"Fangsaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Yuklyaeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,8]]},"reference":[{"key":"e_1_2_12_1_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.41.6750"},{"key":"e_1_2_12_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/20420986211004745"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220910202"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.35399"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-14-0040"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.2217\/imt.14.9"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-12-195792"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-741033"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1089\/cbr.2010.0865"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/857519"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.4161\/intv.22823"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.45.10.1873"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.11.1757"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.51.4.1146"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/3517328","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crom\/3517328","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/3517328","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:04:12Z","timestamp":1773774252000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crom\/3517328"}},"subtitle":[],"editor":[{"given":"Jose I.","family":"Mayordomo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crom\/3517328"],"URL":"https:\/\/doi.org\/10.1155\/crom\/3517328","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3517328"}}