{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T11:31:21Z","timestamp":1786620681570,"version":"build-2736575974"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Leiomyosarcoma (LMS) is a rare and aggressive soft tissue sarcoma known for its propensity for hematogenous dissemination, frequently involving the lungs and pleura. We present a case of metastatic pleuropulmonary LMS managed with a novel combined approach: robotic\u2010assisted cytoreductive surgery and hyperthermic intrathoracic chemotherapy (HITHOC). A 61\u2010year\u2010old male with high\u2010grade LMS developed progressive pleural and pulmonary metastases following prior systemic chemotherapy and palliative radiotherapy. Diagnostic imaging showed enlarging pleural nodules and diaphragmatic thickening, with PET\u2010CT confirming intense hypermetabolic activity confined to the right hemithorax. A multistep robotic\u2010assisted thoracic procedure was performed, including total pleurectomy, pulmonary segmentectomy, mediastinal lymphadenectomy, and HITHOC utilizing cisplatin at 42\u00b0C. The patient achieved an uncomplicated postoperative course and reported complete symptomatic relief of pre\u2010existing pleuritic pain. At 6\u2010months postprocedure, follow\u2010up imaging confirmed isolated local recurrence (two subpleural nodules). However, no regional lymphadenopathy or distant progression was detected. The patient was transitioned to pazopanib therapy, which resulted in radiological stability and maintained symptomatic control through the 12\u2010month postoperative follow\u2010up period. This case demonstrates the feasibility, safety, and therapeutic value of robotic cytoreduction with HITHOC in selected metastatic LMS, achieving complete macroscopic resection and sustained 12\u2010month disease control when integrated with targeted therapy.<\/jats:p>","DOI":"10.1155\/crom\/4409000","type":"journal-article","created":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T09:16:17Z","timestamp":1767345377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Robotic\u2010Assisted Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy in Metastatic Pleuropulmonary Leiomyosarcoma: A Case Report"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8396","authenticated-orcid":false,"given":"Mariana Canevari","family":"de Oliveira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-3973","authenticated-orcid":false,"given":"Paula Duarte","family":"D\u2019Ambrosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Pinheiro","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Carvalho","family":"Marotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Manzano","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Mingarini Terra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-2019-pm-13"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14143329"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.ra.15-00344"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-23-454"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16091691"},{"key":"e_1_2_9_6_2","doi-asserted-by":"crossref","unstructured":"HashimA. A. M. SantanaN. ArbaeenA. SalehW. Al KattanK. andMiglioreM. Bi-centric Experience with Cytoreductive Surgery and Hyperthermic Intra-Thoracic Chemotherapy (HITHOC) for Pleural Malignancies European Respiratory Journal 2024 64 no. 68 https:\/\/doi.org\/10.1183\/13993003.congress-2024.PA1420.","DOI":"10.1183\/13993003.congress-2024.PA1420"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.08.11"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16142513"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23961"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60651-5"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-023-01905-y"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1259779"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/4409000","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crom\/4409000","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/4409000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T10:45:58Z","timestamp":1786617958000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crom\/4409000"}},"subtitle":[],"editor":[{"given":"Harleen","family":"Khatra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crom\/4409000"],"URL":"https:\/\/doi.org\/10.1155\/crom\/4409000","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2025-04-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"4409000"}}