{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T10:25:40Z","timestamp":1787567140700,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T00:00:00Z","timestamp":1787529600000},"content-version":"vor","delay-in-days":235,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Multifocal and multicentric breast cancers are increasingly diagnosed due to advances in imaging. Although some degree of molecular heterogeneity between tumor foci is recognized, most multicentric tumors share similar biological profiles. The presence of synchronous multicentric breast cancer with completely opposing molecular phenotypes remains exceptional.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>We report the case of a 67\u2010year\u2010old woman diagnosed with synchronous multicentric breast cancer of the left breast. One tumor focus showed a HER2\u2010enriched phenotype (ER\u2010negative, PR\u2010negative, HER2\u2010amplified, and Ki67 60%), whereas a second spatially distinct focus (both confirmed on the surgical specimen) exhibited a luminal A phenotype (ER 100%, PR 1%, HER2\u2010negative, and Ki67 15%). Both lesions were confirmed by magnetic resonance imaging and independently biopsied. The patient underwent modified radical mastectomy and received adjuvant anti\u2010HER2 targeted therapy and endocrine therapy. At 22 months of follow\u2010up, she remains disease\u2010free.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the importance of comprehensive imaging assessment and independent molecular characterization of all suspicious tumor foci in multicentric breast cancer, as molecular discordance may have significant prognostic and therapeutic implications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crom\/5068002","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T08:48:55Z","timestamp":1787561335000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Multicentric Breast Cancer With Opposite Molecular Phenotypes: A Case Report and Therapeutic Considerations"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0955-204X","authenticated-orcid":false,"given":"Nelson","family":"Buelvas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2091-763X","authenticated-orcid":false,"given":"Zully","family":"Acevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,24]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60534"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.166"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2010.06.001"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.183.4.1831149"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1851"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4430-6"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/02841860600897884"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.08.026"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.101562"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mds136"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2013.10.006"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.1147"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr570"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.4540"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28375"},{"key":"e_1_2_11_16_2","volume-title":"ACR BI-RADS Atlas, Breast Imaging Reporting and Data System","author":"D\u2019Orsi C. 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G.","year":"2017","journal-title":"Radiologic Technology"},{"key":"e_1_2_11_24_2","volume-title":"NCCN Clinical Practice Guidelines in Oncology - Breast Cancer National Comprehensive Cancer Network","author":"National Comprehensive Cancer Network","year":"2026"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001040050662"},{"key":"e_1_2_11_26_2","first-page":"743","volume-title":"Bland KI","author":"Newman L. 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