{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:38:57Z","timestamp":1792269537507,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T00:00:00Z","timestamp":1788739200000},"content-version":"vor","delay-in-days":249,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Lenalidomide is widely used for the treatment and maintenance of multiple myeloma and is generally considered to have a favorable safety profile. However, severe skeletal muscle toxicity associated with lenalidomide has been rarely reported. We describe a 52\u2010year\u2010old man with multiple myeloma who developed acute bilateral lower\u2010extremity pain, cramping, weakness, and paresthesia while receiving lenalidomide therapy. Laboratory evaluation revealed marked rhabdomyolysis, and imaging and clinical findings were consistent with bilateral lower\u2010leg compartment syndrome. Despite emergent bilateral fasciotomies resulting in resolution of pain and normalization of creatine kinase levels, the patient developed persistent bilateral foot drop with residual sensory deficits. To our knowledge, this represents the first reported case of lenalidomide\u2010associated rhabdomyolysis progressing to bilateral compartment syndrome with permanent neurologic sequelae. This case underscores the importance of early recognition of muscle toxicity, prompt laboratory evaluation, and timely surgical intervention to mitigate irreversible functional impairment.<\/jats:p>","DOI":"10.1155\/crom\/6693120","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:22:20Z","timestamp":1788765740000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lenalidomide\u2010Associated Rhabdomyolysis Progressing to Bilateral Compartment Syndrome and Permanent Foot Drop"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5048-3026","authenticated-orcid":false,"given":"Karthik","family":"Iyer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjna","family":"Chetan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anoohya","family":"Arkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig S.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhaskara","family":"Gadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Popu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikram","family":"Oke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briccio S.","family":"Cadiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,7]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2015-009576"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa022340"},{"key":"e_1_2_13_3_2","first-page":"140","article-title":"Revlimid (Lenalidomide) Now FDA Approved as First-Line Therapy for Patients With Multiple Myeloma","volume":"9","author":"Raedler L. A.","year":"2016","journal-title":"American Health & Drug Benefits"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2017.72.6679"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2017-0440"},{"key":"e_1_2_13_6_2","volume-title":"Rhabdomyolysis","author":"Rout P.","year":"2025"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-025-05189-z"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc2978"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.236"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.632399"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-012-1226-3"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-011-0903-y"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.57181\/ijoimr\/vol10i01\/92"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2362"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.199"},{"key":"e_1_2_13_16_2","volume-title":"The Use of the WHO\u2013UMC System for Standardized Case Causality Assessment","author":"World Health Organization","year":"2013"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v26.i10.1020"}],"container-title":["Case Reports in Oncological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/6693120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crom\/6693120","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crom\/6693120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T07:22:22Z","timestamp":1788765742000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crom\/6693120"}},"subtitle":[],"editor":[{"given":"Lipi","family":"Buch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1155\/crom\/6693120"],"URL":"https:\/\/doi.org\/10.1155\/crom\/6693120","archive":["Portico"],"relation":{},"ISSN":["2090-6706","2090-6714"],"issn-type":[{"value":"2090-6706","type":"print"},{"value":"2090-6714","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6693120"}}