{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:33:07Z","timestamp":1773084787554,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":67,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Oncological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Thoracic SMARCA4\u2010deficient undifferentiated tumor (SMARCA4\u2010UT) of the chest is a highly aggressive smoking\u2010related thoracic malignancy with a median overall survival (OS) of only 4\u20137 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>In this article, we report a case of a 74\u2010year\u2010old male patient who was admitted to the hospital with recurrent cough with sputum and CT suggestive of a right pleural occupying lesion. Admission to the hospital and perfect CT showed right pleural thickening with multiple metastases in the mediastinum and liver, and the diagnosis of SMARCA4\u2010UT (SMARCA4 expression deletion) was confirmed by pathologic biopsy and immunohistochemistry. The genetic test map suggested high PD\u2010L1 expression (TPS 80%) and the patient was treated with sindilizumab (200\u2009mg q3w) combined with bevacizumab (500\u2009mg q3w). Grade 3 immune myocarditis occurred during treatment, and bevacizumab maintenance therapy was continued after discontinuing immunosuppression. During follow\u2010up, the patient achieved a final OS of 18 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This case suggests that PD\u20101 inhibitors combined with antiangiogenic therapy may improve the prognosis of SMARCA4\u2010UT, but the adverse effects observed during the treatment course demanded equally critical attention.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crom\/7148051","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T11:15:02Z","timestamp":1773054902000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010Line Treatment of Advanced Thoracic SMARCA4\u2010Deficient Undifferentiated Tumor: A Case Report and Review of the 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