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It is exceedingly uncommon for SPNs to manifest in extrapancreatic locations, such as the mesocolon, greater omentum, jejunum, and ovary. SPNs are considered very rare, constituting about 0.17%\u20132.5% of all pancreatic neoplasms and 6% of cystic pancreatic neoplasms. We present two pediatric cases of SPNs: one involving a 16\u2010year\u2010old female patient and the other a 14\u2010year\u2010old girl, both diagnosed and treated in our center with surgical resection. The experience of our center confirms that wide margin surgery, with associated metastasectomy if necessary, represents the therapy of choice for SPNs, ensuring effective control of the disease.<\/jats:p>","DOI":"10.1155\/crom\/8183273","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T01:38:32Z","timestamp":1748828312000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Surgical Treatment of Solid Pseudopapillary Tumor in Pediatric Patients: Two Case Reports and a Brief Narrative Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7038-3519","authenticated-orcid":false,"given":"Dario","family":"Talloa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Cordaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Attin\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Mastrangelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Romano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Fregola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palma","family":"Maurizi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorenzo","family":"Nanni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6052-3511","authenticated-orcid":false,"given":"Antonio","family":"Ruggiero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,1]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0000000000000061"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2011.01.013"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.35.137.22404"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.21873\/invivo.13345"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9260(96)80242-x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.02.011"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v13.i8.896"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-013-0015-7"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2019-0473-ra"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9440(10)62563-1"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880255"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10189"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18010081"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2020.1792549"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/mpa.0b013e3181f749d3"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.27114"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1753-2"},{"key":"e_1_2_11_18_2","first-page":"597","article-title":"Solid and Papillary Neoplasm Arising From an Ectopic Pancreas in the Mesocolon","volume":"85","author":"Ishikawa O.","year":"1990","journal-title":"The American Journal of Gastroenterology"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.1020044"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e19318"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2009.01.074"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000005842"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000141"},{"key":"e_1_2_11_24_2","volume-title":"Pathology and Genetics of Tumours of the Digestive System","author":"Hamilton S. 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