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Imaging findings are often nonspecific, and the pathology tends to have overlap with other malignancies. As a result, it can be quite difficult to suspect and diagnose EHE. We present a case of pulmonary EHE in a 41\u2010year\u2010old female with left pleural thickening and subclavian tumor thrombus who was initially misdiagnosed and treated as mesothelioma. This instance demonstrates the importance of maintaining a broad differential and the utilization of repeat biopsies and next\u2010generation sequencing for questionable diagnoses of atypical malignancies.<\/jats:p>","DOI":"10.1155\/crom\/9459565","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:48:41Z","timestamp":1739260121000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epithelioid Hemangioendothelioma (EHE) Mimicking Mesothelioma: Case Presentation and Review"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9751-7000","authenticated-orcid":false,"given":"Kabir","family":"Grewal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7931-9257","authenticated-orcid":false,"given":"Saivaroon","family":"Gajagowni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayanaat","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Son Viet","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2021.100170"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/262674"},{"key":"e_1_2_9_3_2","first-page":"97","volume-title":"World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of the Lung, Pleura, Thymus and Heart","author":"Travis W. 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