{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:38:04Z","timestamp":1773787084560,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":273,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Posterior microphthalmos (PM) typically manifests as retinal thickening, edema, and the presence of papillomacular fold (PMF). We report a case of bilateral PM with macular atrophy and RPE dysfunction. Late\u2010stage of RPE dysfunction in PM is poorly documented in the literature. We present a case that highlights this scenario, aiming to raise awareness of this condition among ophthalmologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>The authors emphasize the atypical imaging findings associated with PM and RPE dysfunction. This case was initially misdiagnosed as macular edema, leading to the administration of anti\u2010VEGF treatment, a common clinical pitfall in PM due to intraretinal cystoid changes. Nevertheless, no improvement was observed in retinal thickness, as evidenced by OCT examination, or inpatient visual acuity following anti\u2010VEGF therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our case adds to recently reported cases linking PM and RPE dysfunction. The recognition of the short axial length and the utilization of imaging modalities such as OCT and FFA contribute to the diagnosis of this condition. It is important to note that anti\u2010VEGF therapy is not applicable for this condition.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crop\/2525345","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T07:05:09Z","timestamp":1759302309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Posterior Microphthalmos With RPE Dysfunction Misdiagnosed as Macular Edema"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6353-548X","authenticated-orcid":false,"given":"Xiaping","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8946-2226","authenticated-orcid":false,"given":"Weiwei","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6045-6546","authenticated-orcid":false,"given":"Shuangnong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6020-2104","authenticated-orcid":false,"given":"Hua","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0359-6925","authenticated-orcid":false,"given":"Yanjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1080\/13816810701651241"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2012.08.016"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2735465"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-022-01889-5"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-019-01115-7"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2008.07.045"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2018.10.007"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S75771"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.4274\/tjo.galenos.2019.40504"},{"key":"e_1_2_13_10_2","first-page":"105","article-title":"Ultrasonics Diagnosis of Microphthalmia Without Microcornea, with Macrophakia, High Hypermetropia Associated With Tapeto-Retinal Degeneration, a Glaucomatous Predisposition and Dental Anomalies (New Familial Syndrome)","volume":"25","author":"Franceschetti A.","year":"1965","journal-title":"Archives D\u2032ophtalmologie et Revue G\u00e9n\u00e9rale D\u2032ophtalmologie"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2015.206"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1983.01040010413014"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312781"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.4103\/0974-9233.129774"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(75)90743-6"}],"container-title":["Case Reports in Ophthalmological Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crop\/2525345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crop\/2525345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crop\/2525345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:59:34Z","timestamp":1773773974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crop\/2525345"}},"subtitle":[],"editor":[{"given":"J. Fernando","family":"Arevalo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crop\/2525345"],"URL":"https:\/\/doi.org\/10.1155\/crop\/2525345","archive":["Portico"],"relation":{},"ISSN":["2090-6722","2090-6730"],"issn-type":[{"value":"2090-6722","type":"print"},{"value":"2090-6730","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-03-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2525345"}}