{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:30:11Z","timestamp":1786429811853,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":221,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study is aimed at reporting a case of choroidal osteoma in a young boy complicated by choroidal neovascularization (CNV) and describing its clinical course over 9 months following intravitreal aflibercept injections.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observation<\/jats:title>\n                    <jats:p>A 7\u2010year\u2010old boy presented with a 2\u2010month history of decreased vision in his left eye. Clinical examination and multimodal imaging revealed a central choroidal osteoma complicated by an active CNV with associated subretinal hemorrhage and fluid. The patient was treated with intravitreal aflibercept under general anesthesia. Follow\u2010up visits demonstrated early anatomical improvement, with resolution of subretinal hemorrhage and fluid. However, recurrent CNV activity and fluctuating visual acuity were observed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Although choroidal osteoma is more commonly reported in adult females, it should also be considered in young boys. Early treatment with aflibercept was associated with short\u2010term anatomical and transient functional improvements in the management of CNV secondary to choroidal osteoma. However, visual acuity fluctuated during follow\u2010up visits, necessitating recurrent CNV injections. Therefore, regular follow\u2010up is essential due to the risk of recurrence and to preserve long\u2010term visual acuity. Given the rarity of this condition, further studies with larger sample sizes and extended follow\u2010up periods are required to evaluate the effectiveness of anti\u2013vascular endothelial growth factor therapy and establish evidence\u2010based management guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crop\/5548292","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T06:03:45Z","timestamp":1786428225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Use of Aflibercept to Treat Choroidal Neovascularization Secondary to Choroidal Osteoma in a 7\u2010Year\u2010Old Child: A Multimodal Imaging Case 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