{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:50:10Z","timestamp":1775746210464,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T00:00:00Z","timestamp":1753488000000},"content-version":"vor","delay-in-days":206,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>The coronavirus disease 2019 (COVID\u201019) primarily involves the respiratory system, but can manifest with a variety of neuro\u2010ophthalmic symptoms. Here, we describe three cases presenting with neuro\u2010ophthalmic manifestations secondary to COVID\u201019 at a tertiary center in Nepal. The first case was a 42\u2010year\u2010old male with sudden onset painless loss of vision noticed in the right eye (RE) after COVID\u201019 infection. Examination findings in the RE showed best corrected visual acuity (BCVA) of 6\/18 with relative afferent pupillary defect positive and superior sectoral disk edema in the same eye. The case was diagnosed as RE nonarteritic ischemic optic neuropathy associated with COVID\u201019 infection. Our second case was a 41\u2010year\u2010old female who developed bilateral sudden diminution of vision associated with headache and vomiting on the third day of testing positive for COVID\u201019 infection. She had bilateral BCVA of 6\/12 and sluggishly reacting pupils in both eyes. Dilated fundus examination showed established disk edema. Imaging of the brain showed dural venous sinus (transverse and sagittal) thrombosis. So, the diagnosis of papilledema secondary to COVID\u201019 associated cerebral venous sinus thrombosis (CVST) was established. The third case was a 40\u2010year\u2010old male with right sixth cranial nerve palsy, ischemic stroke involving the right occipital lobe and posterior limb of the right internal capsule along with thrombosis of the left common iliac artery in the absence of any other preexisting vascular risk factors. Severe inflammatory reaction to COVID\u201019 causing a hypercoagulable state may be the causal factor in neuro\u2010ophthalmic findings in our case series.<\/jats:p>","DOI":"10.1155\/crop\/6694537","type":"journal-article","created":{"date-parts":[[2025,7,26]],"date-time":"2025-07-26T09:21:06Z","timestamp":1753521666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neuro\u2010Ophthalmic Manifestation Associated With COVID\u201019 in a Tertiary Eye Center in Nepal"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5007-2948","authenticated-orcid":false,"given":"Sanjeeta","family":"Sitaula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiranjiwi","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganga 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