{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:24:59Z","timestamp":1786116299513,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":217,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study aims to report a case of tuberculosis involving central nervous system (CNS) discovered thanks to tubercular endophathlmitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This is a case report.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observation<\/jats:title>\n                    <jats:p>\n                      A 14\u2010year\u2010old male presented with acute visual loss, ocular pain, and redness of the right eye following a recent stay in India. The clinical history was notable for prolonged fever, night sweats, and headache. Ophthalmological examination revealed severe intraocular inflammation consistent with panuveitis and endophthalmitis. Neuroimaging demonstrated a large ring\u2010enhancing lesion in the right hemisphere with significant mass effect. Initial microbiological investigations, including vitreous sampling, were negative. A positive interferon\u2010gamma release assay and radiological findings raised suspicion for disseminated tuberculosis, and\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      DNA was subsequently detected in vitreous samples after repeating a second vitrectomy. Antitubercular therapy was started and definitive diagnosis was made with biopsy of the brain lesion, which demonstrated positive cultures for drug\u2010sensitive\n                      <jats:italic>M. tuberculosis<\/jats:italic>\n                      . The clinical course was complicated by retinal detachment, paradoxical enlargement of the cerebral tuberculoma, and postoperative neurological deficits requiring surgical intervention and rehabilitation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlights the diagnostic complexity of ocular and CNS tuberculosis and emphasizes the need for a high index of suspicion, repeated targeted sampling, and multidisciplinary management to achieve timely diagnosis and appropriate treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crop\/8141797","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T09:01:09Z","timestamp":1786006869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["When the Eye Reveals Disseminated Tuberculosis: A Pediatric Case of Endophthalmitis With Severe CNS Involvement"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-5047-4745","authenticated-orcid":false,"given":"Nicola","family":"De Santi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Curci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3423-1071","authenticated-orcid":false,"given":"Eduardo","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1648-0849","authenticated-orcid":false,"given":"Barbara","family":"Iaccheri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0355-2885","authenticated-orcid":false,"given":"Carlo","family":"Pallotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Rosignoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2410-9775","authenticated-orcid":false,"given":"Tito","family":"Fiore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8774-4843","authenticated-orcid":false,"given":"Giuseppe Vittorio Luigi","family":"De Socio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3812-9219","authenticated-orcid":false,"given":"Carlo","family":"Cagini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"e_1_2_10_1_2","volume-title":"Global Tuberculosis Report 2024","author":"World Health Organization","year":"2022"},{"key":"e_1_2_10_2_2","first-page":"1761","article-title":"Extrapulmonary Tuberculosis: An Overview","volume":"72","author":"Golden M. 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