{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:39:23Z","timestamp":1792269563334,"version":"4.4.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":260,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Ophthalmological Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To describe a case of netarsudil\u2010associated honeycomb keratopathy in a patient with iridocorneal endothelial (ICE) syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Observations<\/jats:title>\n                    <jats:p>A 43\u2010year\u2010old male with a history of Cogan\u2013Reese variant ICE syndrome presented with ocular irritation, foreign body sensation, blurred vision, photosensitivity, and discharge in the right eye 2 weeks after initiating topical netarsudil 0.02% for secondary angle\u2010closure glaucoma. Slit lamp exam and anterior segment optical coherence tomography demonstrated diffuse reticular epithelial cysts, consistent with netarsudil\u2010induced honeycomb keratopathy. Three weeks after netarsudil cessation, slit lamp exam showed complete resolution of corneal edema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Importance<\/jats:title>\n                    <jats:p>Endothelial cell dysfunction in ICE syndrome may be a risk factor for patients to develop reversible netarsudil\u2010induced honeycomb keratopathy. Ophthalmologists should exercise caution when prescribing netarsudil for glaucoma management in patients with pre\u2010existing corneal pathologies, including those with ICE syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crop\/8615059","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T05:05:16Z","timestamp":1789794316000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Netarsudil\u2010Induced Honeycomb Keratopathy in an Eye With Iridocorneal Endothelial Syndrome"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9918-3479","authenticated-orcid":false,"given":"Alina N.","family":"Ferguson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-7549","authenticated-orcid":false,"given":"Karine Duarte","family":"Bojikian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2017.11.019"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2019.01.003"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2018.08.004"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-021-02665-0"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000553"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001636"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6139026"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2020.1023"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.04.002"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000538119"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/ijg.0000000000001516"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002621"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2025.5219"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.2147\/opth.s553856"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-024-03342-4"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2018.01.001"},{"key":"e_1_2_11_17_2","first-page":"522","article-title":"Einseitige Spontane Luckenbildung der Iris Durch Atrophie Ohne Mechanische Zerrung","volume":"41","author":"Harms C.","year":"1903","journal-title":"Klin Mbl Augenheilkd"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0039-6257(79)90143-7"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(56)91655-5"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/bf03186675"},{"key":"e_1_2_11_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1976.03910030194004"},{"key":"e_1_2_11_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-858119"},{"key":"e_1_2_11_23_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/763093"},{"key":"e_1_2_11_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1990.01070130074034"},{"key":"e_1_2_11_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/ARCHOPHT.1989.01070020539035"},{"key":"e_1_2_11_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/cells14040258"},{"key":"e_1_2_11_27_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.90624.2007"},{"key":"e_1_2_11_28_2","doi-asserted-by":"publisher","DOI":"10.2131\/fts.1.39"},{"key":"e_1_2_11_29_2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17887"},{"key":"e_1_2_11_30_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136802"},{"key":"e_1_2_11_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101287"},{"key":"e_1_2_11_32_2","unstructured":"Summary of Other Studies (open-Label Extension for APOLLO and LUNAR and JUPITER). 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