{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:06:27Z","timestamp":1779185187065,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":138,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>Within the aerodigestive tract, syphilis presents with varied signs and symptoms, some of which may mimic malignancy or other disease processes. We present the case of a 29\u2010year\u2010old man with otalgia and odynophagia who was found on physical examination and office laryngoscopy to have a 4\u2010cm ulcerative mass of the tongue base and cervical lymphadenopathy. While planning for tissue diagnosis, the patient\u2019s serologies revealed positive treponemal antibody testing and elevated rapid plasma reagin (RPR) titers, confirming syphilitic infection, likely representing secondary syphilis. While awaiting operative biopsy, the patient received intramuscular penicillin with complete resolution of the mass and symptoms, and ultimately operative intervention was deferred. While planning for biopsy of suspicious head and neck lesions, clinicians should consider infectious disease workups in patients with risk factors.<\/jats:p>","DOI":"10.1155\/crot\/2673365","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T09:13:16Z","timestamp":1779181996000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oropharyngeal Syphilis Presenting as Tongue Base Ulcer With Lymphadenopathy"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-6403","authenticated-orcid":false,"given":"Serena F.","family":"Pu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3225-2408","authenticated-orcid":false,"given":"Kevin J.","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-1087","authenticated-orcid":false,"given":"Benjamin J.","family":"Rubinstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"e_1_2_7_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0030-6665(03)00025-2"},{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.30765"},{"key":"e_1_2_7_3_2","unstructured":"Sexually Transmitted Disease Surveillance 2021. 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