{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:43:45Z","timestamp":1773787425516,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":345,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We report a case of osteosarcoma of the mastoid process.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The tumor was identified after the patient presented with progressive hearing loss 5\u2009years after radiotherapy treatment for parotid mucoepidermoid carcinoma. A CT scan revealed a mass invading the middle ear and mastoid process. The diagnosis of osteosarcoma was confirmed by biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mass was surgically excised, and the patient was treated with postoperative cisplatin and doxorubicin. The patient also developed a postauricular abscess that was treated with incision and drainage and antibiotics. This abscess ultimately resolved, and the patient is otherwise well postoperatively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case demonstrates the extent to which osteosarcomas can invade into surrounding tissues as this one had reached the middle ear. Moreover, this case highlights the need for multicenter studies to develop an approach to treatment of these rare tumors as they are not well studied currently.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crot\/6035926","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T07:04:02Z","timestamp":1765609442000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenges in Diagnosis and Management of Mastoid Osteosarcoma: A Case Report and Review of Literature"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9766-0564","authenticated-orcid":false,"given":"Abdullah","family":"Aldaihani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousef","family":"Bolous","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Bullock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nael","family":"Shoman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Trites","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_9_1_2","first-page":"E492","article-title":"Advanced Osteosarcoma of the Maxilla: A Case Report","volume":"13","author":"Amaral M. 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K.","year":"2012","journal-title":"Collegium Antropologicum"},{"key":"e_1_2_9_7_2","first-page":"314","article-title":"Parosteal Osteosarcoma of the Mastoid Bone Following Radiotherapy for Nasopharyngeal Carcinoma","volume":"67","author":"Hsieh S.-T.","year":"2004","journal-title":"Journal of the Chinese Medical Association"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1080\/1357714021000022186"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199701000-00013"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.4103\/indianjotol.INDIANJOTOL_1_19"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-2-6"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199906000-00023"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.03.035"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.dmfr.4600407"}],"container-title":["Case Reports in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crot\/6035926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crot\/6035926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crot\/6035926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:04:44Z","timestamp":1773774284000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crot\/6035926"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crot\/6035926"],"URL":"https:\/\/doi.org\/10.1155\/crot\/6035926","archive":["Portico"],"relation":{},"ISSN":["2090-6765","2090-6773"],"issn-type":[{"value":"2090-6765","type":"print"},{"value":"2090-6773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2024-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6035926"}}