{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T22:43:59Z","timestamp":1773787439870,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":204,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Case Reports in Otolaryngology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    <jats:bold>Introduction:<\/jats:bold>\n                    Sarcomas account for less than 1% of malignant tumors of the larynx. Synovial sarcomas account for 5%\u20137% of all soft tissue sarcomas and 0.1% of sarcomas in the head and neck region.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Clinical Report:<\/jats:bold>\n                    A 45\u2010year\u2010old patient presented with hoarseness of voice and breathing difficulty. Contrast\u2010enhanced computed tomography showed a well\u2010defined mass originating from the laryngeal surface of the epiglottis, obstructing the supraglottis, for which emergency tracheostomy was done. Pathology confirmed monophasic synovial sarcoma. He underwent a supraglottic partial laryngectomy with complete removal of the tumor. The patient is on a 6\u2010month postoperative course, with monthly follow\u2010up, and there is no sign of recurrence.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Discussion:<\/jats:bold>\n                    Clinical diagnosis can be challenging, as patients often present with ill\u2010defined symptoms in the throat and larynx, which may delay diagnosis. The current approach relies on immunohistochemistry analysis for diagnostic purposes, and imaging is generally used to define the tumor location and extent and to rule out other tumors. Most reported studies put surgery as a first\u2010line mode of management, and adjuvant radiotherapy is currently advocated, as it is associated with better overall survival. Synovial sarcoma is considered a high\u2010grade tumor, although head and neck subsites tend to have a slightly better prognosis. Tumor size of more than 5\u2009cm and higher tumor stage are associated with poor overall survival.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:<\/jats:bold>\n                    Synovial sarcoma of the larynx is a rare clinical entity, and every case should be examined individually.\n                  <\/jats:p>","DOI":"10.1155\/crot\/6112967","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:06:29Z","timestamp":1753355189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Primary Laryngeal Synovial Sarcoma, Challenges in Diagnosis and Management in a Resource\u2010Limited Setup: A Case Report"],"prefix":"10.1155","volume":"2025","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-0102","authenticated-orcid":false,"given":"Mikiyas","family":"Olani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mesele","family":"Bogale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suleman","family":"Essa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanuel","family":"Damie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eyerusalem","family":"Fekade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sosna","family":"Ngusie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"e_1_2_11_1_2","unstructured":"AndrewJ. M. V. Primary Sarcomas of the Larynx: A Clinicopathologic Study of 27 Cases-Pubmed https:\/\/pubmed.ncbi.nlm.nih.gov\/33686585\/."},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnci.2018.10.002"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1077756"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(98)80042-7"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-005-0024-z"},{"key":"e_1_2_11_6_2","article-title":"Laryngeal Synovial Sarcoma: A Systematic Review of the Last 40 Years of Reported Cases-Gregory Shein","author":"Antoinette G. S.","year":"2021","journal-title":"Gurfateh Sandhu, Alison Potter, Christine Loo, Ian Jacobson, Antoinette Anazodo"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6134845"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.169.4.9308488"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.xocr.2021.100342"},{"key":"e_1_2_11_10_2","first-page":"851","article-title":"Synovial Sarcomas of the Head and Neck: CT and MR Imaging Findings of Eight Patients","volume":"22","author":"Rangheard A. S.","year":"2001","journal-title":"AJNR American Journal of Neuroradiology"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213330.71745.39"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800569"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2634"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20386"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.0384"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2013-0027"}],"container-title":["Case Reports in Otolaryngology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crot\/6112967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1155\/crot\/6112967","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/crot\/6112967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T19:05:06Z","timestamp":1773774306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/crot\/6112967"}},"subtitle":[],"editor":[{"given":"Marco","family":"Berlucchi","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1155\/crot\/6112967"],"URL":"https:\/\/doi.org\/10.1155\/crot\/6112967","archive":["Portico"],"relation":{},"ISSN":["2090-6765","2090-6773"],"issn-type":[{"value":"2090-6765","type":"print"},{"value":"2090-6773","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2025-01-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"6112967"}}