{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:58:12Z","timestamp":1790416692923,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":268,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Naples Prognostic Score (NPS) is a composite inflammatory\u2010nutritional index that integrates serum albumin, total cholesterol, neutrophil\u2010to\u2010lymphocyte ratio, and lymphocyte\u2010to\u2010monocyte ratio to predict outcomes in acute myocardial infarction (MI); however, its independent prognostic value remains incompletely defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the correlation between the NPS and outcomes in patients with acute MI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched PubMed, Scopus, Cochrane, Embase, and Wiley Online Library for studies evaluating the NPS in patients with acute MI. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random\u2010effects models, and heterogeneity was assessed using the I\n                      <jats:sup>2<\/jats:sup>\n                      statistic.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nine observational cohort studies comprising 15,998 patients with MI were analyzed. Higher NPS was associated with increased odds of all\u2010cause mortality (OR 3.31; 95% CI: 1.62\u20136.77,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0130), no\u2010reflow phenomenon (OR 1.40; 95% CI 1.11\u20131.76;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.0248), and new\u2010onset atrial fibrillation (OR 2.17; 95% CI: 1.62\u20132.91;\n                      <jats:italic>p<\/jats:italic>\n                      = 0.008). The association with in\u2010hospital mortality did not reach statistical significance in the primary pooled analysis (OR 1.90; 95% CI: 0.66\u20135.44,\n                      <jats:italic>p<\/jats:italic>\n                      = 0.147), with substantial heterogeneity driven by a single influential study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher NPS was correlated with higher risk of all\u2010cause mortality, no\u2010reflow phenomenon, and new\u2010onset atrial fibrillation in patients with acute MI. All estimates are based on observational data that have not been adjusted for any factors; there were three to four cohorts per outcome, and eight of nine studies were from one country. The findings are exploratory and do not warrant the use of NPS as a clinical risk stratification tool; future, adjusted, multinational validation is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/4613242","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:02:10Z","timestamp":1790413330000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Associations of the Naples Score for Clinical Outcomes in Patients With Acute Myocardial Infarction: A Systematic Review and a Prognostic Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6003-4873","authenticated-orcid":false,"given":"Muhammad Sharjeel","family":"Abbas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6439-6263","authenticated-orcid":false,"given":"Tayyaba","family":"Hameed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1842-8684","authenticated-orcid":false,"given":"Rom\u00e1n Rodr\u00edguez","family":"Mil\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6623-9185","authenticated-orcid":false,"given":"Hooria","family":"Sakina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2260-9081","authenticated-orcid":false,"given":"Muhammad","family":"Junaid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1952-6205","authenticated-orcid":false,"given":"Musab Riyan","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7720-0738","authenticated-orcid":false,"given":"Mansoor","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1572-3337","authenticated-orcid":false,"given":"Joao Victor","family":"Silva Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3092-922X","authenticated-orcid":false,"given":"Warisha","family":"Kanwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3612-0087","authenticated-orcid":false,"given":"Ashfaq","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3563-4211","authenticated-orcid":false,"given":"Kristine","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2078-9593","authenticated-orcid":false,"given":"Anuraj Mambazhathu","family":"Sudhakaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1817-7800","authenticated-orcid":false,"given":"Hasibullah","family":"Aminpoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2254-3489","authenticated-orcid":false,"given":"Nehikhare","family":"Ekhator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3580-0783","authenticated-orcid":false,"given":"Mrunalini","family":"Dandamudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"e_1_2_11_2_2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/eurheartj\/ehx393","article-title":"2017 ESC Guidelines for the Management of Acute Myocardial Infarction in Patients Presenting With ST-Segment Elevation","volume":"39","author":"Ibanez B.","year":"2018","journal-title":"European Heart Journal"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1457498"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.284.7.835"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38985.646481.55"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"e_1_2_11_7_2","first-page":"S9","article-title":"Inflammation, Atherosclerosis, and Cardiovascular Risk: an Epidemiologic View","volume":"10","author":"Ridker P. 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