{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:55:29Z","timestamp":1791449729056,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":280,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Both trimethylamine\u2010N\u2010oxide (TMAO) and\n                      <jats:italic>Helicobacter pylori<\/jats:italic>\n                      (\n                      <jats:italic>H. pylori<\/jats:italic>\n                      ) have been linked to atherosclerosis and carotid plaque development. This study examined the associations of\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and plasma TMAO levels with carotid plaque in a health screening population.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Between October 2022 and September 2023, 1779 participants undergoing routine health examinations, including carotid ultrasonography and\n                      <jats:italic>H. pylori<\/jats:italic>\n                      testing, were enrolled. Multivariable logistic regression was used to evaluate the association between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection and carotid plaque. Inverse probability weighting (IPW) was applied to address selection bias in the TMAO subgroup, followed by weighted logistic regression analyses.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Carotid plaque was more prevalent among\n                      <jats:italic>H. pylori<\/jats:italic>\n                      \u2010seropositive participants than among seronegative participants (53.96% vs. 40.37%,\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). In multivariable logistic regression analyses,\n                      <jats:italic>H. pylori<\/jats:italic>\n                      seropositivity remained significantly associated with carotid plaque after adjustment for demographic characteristics and cardiovascular risk factors, with odds ratios ranging from 3.099 to 3.392 across the adjusted models (all\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.001). Higher TMAO levels were associated with carotid plaque in unadjusted analyses and remained associated after adjustment for demographic and conventional cardiovascular risk factors; however, these associations were attenuated and became statistically non\u2010significant after further adjustment for age. No significant association was observed between\n                      <jats:italic>H. pylori<\/jats:italic>\n                      seropositivity and plasma TMAO levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:italic>H. pylori<\/jats:italic>\n                      infection was associated with carotid plaque in this cross\u2010sectional study. The association between TMAO and carotid plaque appeared to be largely explained by age. Given the cross\u2010sectional design, causal relationships cannot be inferred, and further prospective studies are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/5468109","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T08:35:23Z","timestamp":1791448523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Relationship Between\n                    <i>Helicobacter pylori<\/i>\n                    , Trimethylamine\u2010N\u2010Oxide, and Carotid Plaque Formation Among Adult Health Checkup Population in China"],"prefix":"10.1155","volume":"2026","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5760-2238","authenticated-orcid":false,"given":"Fang","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Kaifeng Central Hospital  Kaifeng 475000 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6358-593X","authenticated-orcid":false,"given":"Lina","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaifeng Central Hospital  Kaifeng 475000 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6919-8190","authenticated-orcid":false,"given":"Xia","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaifeng Central Hospital  Kaifeng 475000 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7135-4977","authenticated-orcid":false,"given":"Yaoze","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Queshan County People\u2019s Hospital  Queshan 463200 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4034-3010","authenticated-orcid":false,"given":"Xiangdong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Queshan County People\u2019s Hospital  Queshan 463200 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6113-3560","authenticated-orcid":false,"given":"Yihan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kaifeng Central Hospital  Kaifeng 475000 Henan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0227-3439","authenticated-orcid":false,"given":"Yue","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Biotecan Pharmaceuticals Co., Ltd.  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