{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T09:14:36Z","timestamp":1783415676449,"version":"3.54.6"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":187,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100011479","name":"Baotou Medical College","doi-asserted-by":"publisher","award":["BYJJ-ZRQM 202211"],"award-info":[{"award-number":["BYJJ-ZRQM 202211"]}],"id":[{"id":"10.13039\/501100011479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:p>\n                    This study aimed to investigate the potential molecular mechanisms underlying the therapeutic effects of the traditional Mongolian medicine Zadi\u20105 on coronary heart disease (CHD). The active compounds of Zadi\u20105 were identified using the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform, and their corresponding targets were retrieved from HERB. The GSE42148 dataset was used to analyze differentially expressed genes (DEGs) associated with CHD. A compound\u2013target network and a disease\u2013gene\u2013target network were constructed, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. Molecular docking was performed to predict binding modes. Furthermore, we employed a CHD model with high\u2010fat diet\u2013fed ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice to explore the protective effects of Zadi\u20105 in CHD. A total of 250 targets related to the active compounds in Zadi\u20105 were identified. Additionally, 480 DEGs were screened from the GSE42148 dataset, and seven key targets (MPO, IFNG, TOP2A, PTGS2, CYP2J2, F7, and PPARG) were identified. Molecular docking predicted strong binding affinities between PPARG and the main active components of Zadi\u20105. Furthermore, Zadi\u20105 markedly enhanced the heart performance and reduced fibrotic and inflammatory responses in vivo. Zadi\u20105 effectively suppressed the levels of HIF\u20101\u03b1 and increased the PPARG levels in ApoE\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice post\u2010myocardial infarction. These findings suggest that the active components of Zadi\u20105 may exert therapeutic effects in CHD by targeting PPARG, as revealed by network pharmacology and molecular docking analyses.\n                  <\/jats:p>","DOI":"10.1155\/crp\/5479556","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:27:58Z","timestamp":1783412878000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Network Pharmacology Analysis and Experimental Validation of Zadi\u20105 Against Coronary Heart 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