{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:06:44Z","timestamp":1779692804693,"version":"3.53.1"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,5,24]],"date-time":"2026-05-24T00:00:00Z","timestamp":1779580800000},"content-version":"vor","delay-in-days":143,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cardiology Research and Practice"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The objective of this study was to assess whether interleukin\u201017 or 18 (IL\u201017 or IL\u201018), regulatory T cells (Tregs), and T helper17 (Th17) serum concentrations were different in chronic heart failure not associated with myocarditis compared to healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We searched MEDLINE and Embase for studies with data on IL\u201017 or IL\u201018 serum concentrations in patients with chronic heart failure. Forest plots were used to quantify results and depict the standard difference of means, 95% confidence interval (CI), and\n                      <jats:italic>p<\/jats:italic>\n                      value. Continuous outcomes were assessed as weighted mean differences (WMD) with their 95% CI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      IL\u201017 was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) higher in patients with heart failure. The combined effect size under the random effects model (MD\u2009=\u200940.00 pg\/mL, 95% CI [6.04, 73.96],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) showed a significant overall increase in IL\u201017 serum levels in heart failure. Th17 was significantly (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) higher in patients with heart failure, and Tregs are significantly lower compared to persons without heart failure. The random effects model indicates an MD of 1.59\u2009pg\/mL (95% CI [0.88, 2.30]), highlighting significant elevation of TH17 levels in heart failure. For Tregs, the random effects model presented an MD of \u22122.96\u2009pg\/mL (95% CI [\u22124.52, \u22121.40]), both indicating a significant decrease in Treg levels in HF. Additionally, serum IL\u201017 concentrations correlated with the severity of the reduction in LV ejection fraction. For IL\u201018, all (five) studies reported a statistically significant increase in IL\u201018 levels in HF. The pooled mean difference was 251.59\u2009pg\/mL (95% CI: 177.24\u2013325.93\u2009pg\/mL) with a random effects model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Serum IL\u201017, IL\u201018 Th17, and Treg count have utility for risk stratification for patients with heart failure, as biomarkers for heart failure severity and potential target pathways for treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1155\/crp\/5979003","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T07:00:20Z","timestamp":1779692420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Interleukin\u201017, Interleukin\u201018, T Regulatory Cells, and T\u2010Helper 17 (Th17) Cells Play a Role in Heart Failure: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1155","volume":"2026","author":[{"given":"Sohat","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayant","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6866-5855","authenticated-orcid":false,"given":"Cameron J.","family":"Leong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8923-1152","authenticated-orcid":false,"given":"Simon W.","family":"Rabkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,24]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.121.318172"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.746494"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.115.002225"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.12.006"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038010"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00628.x"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6363(03)00362-6"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-00580-6"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.732794"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00028.2019"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M411787200"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40119-018-0104-3"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00289"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004105"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.25011\/cim.v32i2.6032"},{"key":"e_1_2_13_16_2","doi-asserted-by":"publisher","DOI":"10.4238\/gmr.15028014"},{"key":"e_1_2_13_17_2","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.18-422"},{"key":"e_1_2_13_18_2","volume-title":"Covidence Systematic Review Software","year":"2024"},{"key":"e_1_2_13_19_2","doi-asserted-by":"publisher","DOI":"10.2143\/AC.64.2.2036138"},{"key":"e_1_2_13_20_2","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.699096"},{"key":"e_1_2_13_21_2","unstructured":"XiaojunS. 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